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    INCENP inner centromere protein [ Homo sapiens (human) ]

    Gene ID: 3619, updated on 5-Nov-2017
    Official Symbol
    INCENPprovided by HGNC
    Official Full Name
    inner centromere proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6058
    See related
    Ensembl:ENSG00000149503 MIM:604411; Vega:OTTHUMG00000167470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more
    Orthologs
    Location:
    11q12.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (62123973..62155474)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61891445..61920635)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 37 Neighboring gene uncharacterized LOC100507521 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene secretoglobin family 1D member 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
    NHGRI GWA Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates INCENP in HeLa cells within 12 hours of exposure PubMed
    vpr HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and INCENP/CPC after prophase PubMed
    vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Aurora C signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora C signaling, organism-specific biosystem
      Aurora C signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ31633, MGC111393

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein sumoylation TAS
    Traceable Author Statement
    more info
     
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    central element IEA
    Inferred from Electronic Annotation
    more info
     
    chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral element IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    inner centromere protein
    Names
    binds and activates aurora-B and -C in vivo and in vitro
    chromosomal passenger protein
    inner centromere protein INCENP
    inner centromere protein antigens 135/155kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040694.1NP_001035784.1  inner centromere protein isoform 1

      See identical proteins and their annotated locations for NP_001035784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP002793, AW839685, BC098576, BC111732, CV569756
      Consensus CDS
      CCDS44624.1
      UniProtKB/Swiss-Prot
      Q9NQS7
      Related
      ENSP00000378295.3, OTTHUMP00000236001, ENST00000394818.7, OTTHUMT00000394723
      Conserved Domains (2) summary
      pfam03941
      Location:831882
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    2. NM_020238.2NP_064623.2  inner centromere protein isoform 2

      See identical proteins and their annotated locations for NP_064623.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AP002793, AW839685, BC032678, BC098576, BC111732, CV569756
      Consensus CDS
      CCDS31582.1
      UniProtKB/Swiss-Prot
      Q9NQS7
      Related
      ENSP00000278849.4, OTTHUMP00000236061, ENST00000278849.4, OTTHUMT00000394850
      Conserved Domains (3) summary
      pfam03941
      Location:827878
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      62123973..62155474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544995.2XP_011543297.1  inner centromere protein isoform X1

      Conserved Domains (2) summary
      pfam03941
      Location:846897
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    2. XM_006718533.2XP_006718596.1  inner centromere protein isoform X5

      Conserved Domains (2) summary
      pfam03941
      Location:835886
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    3. XM_011544996.2XP_011543298.1  inner centromere protein isoform X2

      Conserved Domains (2) summary
      pfam03941
      Location:842893
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    4. XM_011544998.2XP_011543300.1  inner centromere protein isoform X4

      Conserved Domains (3) summary
      pfam03941
      Location:838889
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit
    5. XM_011544997.2XP_011543299.1  inner centromere protein isoform X3

      Conserved Domains (3) summary
      pfam03941
      Location:842893
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      61774635..61803822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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