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    EPRS glutamyl-prolyl-tRNA synthetase [ Homo sapiens (human) ]

    Gene ID: 2058, updated on 6-Aug-2017
    Official Symbol
    EPRSprovided by HGNC
    Official Full Name
    glutamyl-prolyl-tRNA synthetaseprovided by HGNC
    Primary source
    HGNC:HGNC:3418
    See related
    Ensembl:ENSG00000136628 MIM:138295; Vega:OTTHUMG00000037433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EARS; PARS; QARS; QPRS; PIG32; GLUPRORS
    Summary
    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q41
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (219968600..220046658, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220141940..220220000, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372926 Neighboring gene RNA, 5S ribosomal pseudogene 76 Neighboring gene uncharacterized LOC107985281 Neighboring gene solute carrier family 30 member 10 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene uncharacterized LOC105373475 Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify glutamyl-prolyl-tRNA synthetase (EPRS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify glutamyl-prolyl-tRNA synthetase (EPRS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify glutamyl-prolyl-tRNA synthetase (EPRS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated glutamyl-prolyl-tRNA synthetase (EPRS, Bifunctional glutamate/proline tRNA ligase) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify glutamyl-prolyl-tRNA synthetase (EPRS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    matrix gag HIV-1 MA is identified to have a physical interaction with glutamyl-prolyl-tRNA synthetase (EPRS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp313B047

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glutamate-tRNA ligase activity TAS
    Traceable Author Statement
    more info
     
    proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proline-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proline-tRNA ligase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    prolyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    GAIT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    bifunctional glutamate/proline--tRNA ligase
    Names
    bifunctional aminoacyl-tRNA synthetase
    cell proliferation-inducing gene 32 protein
    glutamate tRNA ligase
    glutamatyl-prolyl-tRNA synthetase
    glutaminyl-tRNA synthetase
    proliferation-inducing gene 32 protein
    proliferation-inducing protein 32
    proline-tRNA ligase
    prolyl-tRNA synthetase
    NP_004437.2
    XP_016856103.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004446.2NP_004437.2  bifunctional glutamate/proline--tRNA ligase

      See identical proteins and their annotated locations for NP_004437.2

      Status: REVIEWED

      Source sequence(s)
      AA196283, AY493416, BC034797, BC046156, N85252
      Consensus CDS
      CCDS31027.1
      UniProtKB/Swiss-Prot
      P07814
      Related
      ENSP00000355890.3, OTTHUMP00000035562, ENST00000366923.7, OTTHUMT00000091133
      Conserved Domains (9) summary
      cd10309
      Location:74157
      GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
      PLN02907
      Location:13711
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:10191512
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:10231286
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:12921512
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      cd00936
      Location:904952
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:753805
      WHEP-TRS; WHEP-TRS domain
      pfam00749
      Location:197502
      tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
      pfam03950
      Location:504681
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      219968600..220046658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000614.1XP_016856103.1  bifunctional glutamate/proline--tRNA ligase isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      221414886..221492894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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