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    mth methuselah [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38058, updated on 26-Jan-2017
    Official Symbol
    mthprovided by FlyBase
    Official Full Name
    methuselahprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023000
    Locus tag
    Dmel_CG6936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6936; Dmel\CG6936; Mth; MTH
    Location:
    61C1-61C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (343378..346957, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (343378..346957, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah-like 9 Neighboring gene methuselah-like 10 Neighboring gene CG1231 gene product from transcript CG1231-RA Neighboring gene Regulator of cullins 1b Neighboring gene Cell division cycle 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    G-protein coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G-protein coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aging TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    determination of adult lifespan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan TAS
    Traceable Author Statement
    more info
    PubMed 
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to heat NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to heat TAS
    Traceable Author Statement
    more info
    PubMed 
    response to oxidative stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to starvation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to starvation TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CG6936 gene product from transcript CG6936-RB
    Names
    CG6936-PA
    CG6936-PB
    CG6936-PE
    methusalah
    methuselah
    mth-PA
    mth-PB
    mth-PE

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      343378..346957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167829.3NP_728521.1  methuselah, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97148
      Related
      FBpp0072470, FBtr0072571
      Conserved Domains (2) summary
      pfam06652
      Location:29209
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:219416
      7tm_4; Olfactory receptor
    2. NM_079147.4NP_523871.1  methuselah, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97148
      UniProtKB/TrEMBL
      E1JHX3
      Related
      FBpp0072469, FBtr0072570
      Conserved Domains (2) summary
      pfam06652
      Location:29209
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:219416
      7tm_4; Olfactory receptor
    3. NM_001259606.2NP_001246535.1  methuselah, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246535.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97148
      UniProtKB/TrEMBL
      E1JHX3
      Related
      FBpp0297746, FBtr0306850
      Conserved Domains (2) summary
      pfam06652
      Location:29209
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:219416
      7tm_4; Olfactory receptor
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