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    CASP5 caspase 5 [ Homo sapiens (human) ]

    Gene ID: 838, updated on 6-Dec-2016
    Official Symbol
    CASP5provided by HGNC
    Official Full Name
    caspase 5provided by HGNC
    Primary source
    HGNC:HGNC:1506
    See related
    Ensembl:ENSG00000137757 MIM:602665; Vega:OTTHUMG00000048073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICH-3; ICEREL-III; ICE(rel)III
    Summary
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
    Orthologs
    Location:
    11q22.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (104994240..105023902, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104864967..104893895, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene caspase 4, apoptosis-related cysteine peptidase pseudogene Neighboring gene caspase 4 Neighboring gene caspase 1 Neighboring gene caspase recruitment domain family member 16

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC141966

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    pyroptosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    substantia nigra development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT AIM2 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NLRP1 inflammasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT NLRP3 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    caspase-5
    Names
    CASP-5
    ICE(rel)-III
    TY protease
    caspase 5, apoptosis-related cysteine peptidase
    caspase 5, apoptosis-related cysteine protease
    protease ICH-3
    protease TY
    NP_001129581.1
    NP_001129582.1
    NP_001129584.1
    NP_004338.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136109.1NP_001129581.1  caspase-5 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) is lacking an in-frame coding exon compared to transcript variant a, resulting in a shorter isoform (b) missing a 58 aa protein segment compared to isoform a.
      Source sequence(s)
      AK296660, DQ228673, DR005081, X94993
      Consensus CDS
      CCDS44719.1
      UniProtKB/Swiss-Prot
      P51878
      Related
      ENSP00000388365, OTTHUMP00000209889, ENST00000444749, OTTHUMT00000344191
      Conserved Domains (2) summary
      smart00115
      Location:125374
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cl14633
      Location:584
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. NM_001136110.1NP_001129582.1  caspase-5 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) is lacking two consecutive in-frame coding exons compared to transcript variant a, resulting in a shorter isoform (c) missing a 142 aa protein segment compared to isoform a.
      Source sequence(s)
      AK296660, DQ228674, X94993
      Consensus CDS
      CCDS44718.1
      UniProtKB/Swiss-Prot
      P51878
      Related
      ENSP00000398130, ENST00000418434
      Conserved Domains (1) summary
      smart00115
      Location:41290
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    3. NM_001136112.1NP_001129584.1  caspase-5 isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) uses an in-frame, alternate acceptor splice site at an internal coding exon compared to transcript variant a, resulting in a longer isoform (f) containing an additional 13 aa protein segment compared to isoform a.
      Source sequence(s)
      AK296660, DQ228677, DR005081, X94993
      Consensus CDS
      CCDS44720.1
      UniProtKB/Swiss-Prot
      P51878
      Related
      ENSP00000376849, ENST00000393141
      Conserved Domains (2) summary
      smart00115
      Location:196445
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cl14633
      Location:76155
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. NM_004347.3NP_004338.3  caspase-5 isoform a precursor

      See identical proteins and their annotated locations for NP_004338.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes isoform a.
      Source sequence(s)
      AK296660, DQ228672, DR005081, X94993
      Consensus CDS
      CCDS8328.2
      UniProtKB/Swiss-Prot
      P51878
      Related
      ENSP00000260315, OTTHUMP00000045729, ENST00000260315, OTTHUMT00000109397
      Conserved Domains (2) summary
      smart00115
      Location:183432
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cl14633
      Location:63142
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. NR_024239.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) is missing two internal coding exons compared to transcript variant a. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). There is a publication (PMID:16893518) reporting the expression of this transcript, hence it is represented as a variant RefSeq, however, the predicted protein is not represented because it is significantly truncated.
      Source sequence(s)
      AK296660, DQ228676, DR005081, X94993
      Related
      ENST00000456200, OTTHUMT00000344192
    2. NR_036562.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) lacks three alternate internal exons, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK296660, DQ228675, X94993

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      104994240..105023902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543021.2XP_011541323.1  

      Conserved Domains (2) summary
      cl00042
      Location:183317
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cl14633
      Location:63142
      DD; Death Domain Superfamily of protein-protein interaction domains

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      104747902..104776824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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