Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    CD74 CD74 molecule [ Homo sapiens (human) ]

    Gene ID: 972, updated on 8-May-2017
    Official Symbol
    CD74provided by HGNC
    Official Full Name
    CD74 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1697
    See related
    Ensembl:ENSG00000019582 MIM:142790; Vega:OTTHUMG00000163559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    II; DHLAG; HLADG; Ia-GAMMA
    Summary
    The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    5q33.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (150401637..150412936, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149781200..149792543, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378226 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene ribosomal protein S14 Neighboring gene NDST1 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is able to activate the ERK/MAPK pathway by binding to CD74 PubMed
    env HIV-1 gp41 directly interacts with CD74 in HIV-1 infected cells. The loop region (residues 590-624) of gp41 is required to interact with CD74 extracellular domain (residues 72-232) PubMed
    Nef nef HIV-1 Nef cloned from subjects with early/acute progressive HIV infection upregulates CD74 (Ii) in 721.221 cells to a greater extent relative to HIV-1 Nef cloned from subjects with chronic progressive infection PubMed
    nef HIV-1 group N and group O Nef alleles upregulate surface expression of invariant chain (Ii) associated with immature major histocompatibility complex (MHC) class II PubMed
    nef Upregulation of Ii expression by Nef at the cell surface impairs mature MHC class II antigen presentation PubMed
    nef HIV-1 Nef clones, isolated from plasma of elite controllers (EC) and chronic progressors (CP), show significantly lower HLA class II invariant chain (CD74) upregulation activity in EC than that in CP PubMed
    nef Two primary Nef alleles from HIV-1 subtype C and F impair for the MHC-II-associated chaperone invariant chain (Ii) upregulation PubMed
    nef Nef-mediated Ii upregulation depends on the AP-2 mu2 expression pathway PubMed
    nef LL164 and DD174 motifs in HIV-1 Nef and the Ii cytoplasmic tail (amino acids 1-17) are required for the Nef-mediated upregulation of Ii by slowing the rate of Ii internalization PubMed
    nef Substitution of HIV-1 Nef acidic residue E160 with uncharged residues impairs the ability of Nef to upregulate the expression of DC-SIGN and the invariant chain of MHC class II at the cell surface PubMed
    nef HIV-1 Nef induces drastic and moderate downregulation of CD4 and MHC-I in resting CD4(+) T lymphocytes, respectively, but markedly upregulates cell surface levels of the MHC-II invariant chain CD74 PubMed
    Vpu vpu HIV-1 Vpu interacts with CD74 and modulates MHC II in HIV-1-infected cells. The N-terminal 30 amino acids of CD74 are required for the interaction of CD74 with Vpu PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ98970

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CD4 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    MHC class II protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    MHC class II protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    MHC class II protein binding, via antigen binding groove IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MHC class II protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-amyloid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    macrophage migration inhibitory factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell selection NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation of endogenous antigen NAS
    Non-traceable Author Statement
    more info
    PubMed 
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone mediated protein folding requiring cofactor IEA
    Inferred from Electronic Annotation
    more info
     
    defense response IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    macrophage migration inhibitory factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mature B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptide secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic cell antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of monocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of macrophage activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with MHC class II protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOS2-CD74 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular TAS
    Traceable Author Statement
    more info
    PubMed 
    lysosomal lumen TAS
    Traceable Author Statement
    more info
     
    lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    macrophage migration inhibitory factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     
    transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    HLA class II histocompatibility antigen gamma chain
    Names
    CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
    CD74 molecule, major histocompatibility complex, class II invariant chain
    HLA-DR antigens-associated invariant chain
    HLA-DR-gamma
    Ia-associated invariant chain
    MHC HLA-DR gamma chain
    gamma chain of class II antigens
    p33

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029730.1 RefSeqGene

      Range
      5001..16300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025158.2NP_001020329.1  HLA class II histocompatibility antigen gamma chain isoform c

      See identical proteins and their annotated locations for NP_001020329.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons in the 3' coding region, which results in a frame-shift, compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC024272, DC354760
      Consensus CDS
      CCDS34276.1
      UniProtKB/Swiss-Prot
      P04233
      Related
      ENSP00000367026.3, OTTHUMP00000224284, ENST00000377795.7, OTTHUMT00000374177
      Conserved Domains (1) summary
      pfam09307
      Location:17128
      MHC2-interact; CLIP, MHC2 interacting
    2. NM_001025159.2NP_001020330.1  HLA class II histocompatibility antigen gamma chain isoform a

      See identical proteins and their annotated locations for NP_001020330.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK297889, BC024272, DC354760
      Consensus CDS
      CCDS47309.1
      UniProtKB/Swiss-Prot
      P04233
      Related
      ENSP00000009530.7, OTTHUMP00000224285, ENST00000009530.11, OTTHUMT00000374178
      Conserved Domains (3) summary
      cd00191
      Location:212271
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam08831
      Location:136204
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:17128
      MHC2-interact; CLIP, MHC2 interacting
    3. NM_004355.3NP_004346.1  HLA class II histocompatibility antigen gamma chain isoform b

      See identical proteins and their annotated locations for NP_004346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment in the C-terminal region, compared to isoform a.
      Source sequence(s)
      BC018726, BC024272, DC354760
      Consensus CDS
      CCDS47308.1
      UniProtKB/Swiss-Prot
      P04233
      Related
      ENSP00000230685.6, OTTHUMP00000224283, ENST00000353334.10, OTTHUMT00000374176
      Conserved Domains (2) summary
      pfam08831
      Location:136204
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:17128
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      150401637..150412936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010090.1XP_016865579.1  HLA class II histocompatibility antigen gamma chain isoform X2

    2. XM_017010089.1XP_016865578.1  HLA class II histocompatibility antigen gamma chain isoform X1

      Related
      ENSP00000430614.1, OTTHUMP00000224286, ENST00000518797.5, OTTHUMT00000374179

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      149213619..149224915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center