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    SYK spleen associated tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 6850, updated on 22-Apr-2017
    Official Symbol
    SYKprovided by HGNC
    Official Full Name
    spleen associated tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:11491
    See related
    Ensembl:ENSG00000165025 MIM:600085; Vega:OTTHUMG00000020200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p72-Syk
    Summary
    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    9q22.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (90801680..90898560)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (93564012..93660842)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 109 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 108 pseudogene Neighboring gene uncharacterized LOC105379829 Neighboring gene uncharacterized LOC105376143 Neighboring gene uncharacterized LOC100507103 Neighboring gene uncharacterized LOC105376144

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    NHGRI GWA Catalog
    A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
    NHGRI GWA Catalog
    Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia.
    NHGRI GWA Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I PubMed
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with SYK PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
      Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • Atypical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Atypical NF-kappaB pathway, organism-specific biosystem
      Atypical NF-kappaB pathway
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
      C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
    • CLEC7A (Dectin-1) signaling, organism-specific biosystem (from REACTOME)
      CLEC7A (Dectin-1) signaling, organism-specific biosystemCLEC7A (also known as Dectin-1) is a pattern-recognition receptor (PRR) expressed by myeloid cells (macrophages, dendritic cells and neutrophils) that detects pathogens by binding to beta-1,3-glucans...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • Dectin-2 family, organism-specific biosystem (from REACTOME)
      Dectin-2 family, organism-specific biosystemDendritic cell-associated C-type lectin-2 (Dectin-2) family of C-type lectin receptors (CLRs) includes Dectin-2 (CLEC6A), blood dendritic antigen 2 (BDCA2/CLEC4C), macrophage C-type lectin (MCL/CLEC4...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • FCERI mediated Ca+2 mobilization, organism-specific biosystem (from REACTOME)
      FCERI mediated Ca+2 mobilization, organism-specific biosystemIncrease of intracellular calcium in mast cells is most crucial for mast cell degranulation. Elevation of intracellular calcium is achieved by activation of PLC-gamma. Mast cells express both PLC-gam...
    • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
      FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
    • FCGR activation, organism-specific biosystem (from REACTOME)
      FCGR activation, organism-specific biosystemCross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the ...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin 3 (IL-3) is a potent growth factor belonging to the super family of cytokines. IL-3 is a 20- 32kDa glycoprotein involved in the process of hematopoiesis. It is involved in the proliferati...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5 is a glycoprotein which belongs to the cytokine superfamily. It possesses the four helical bundle motifs that is conserved among ...
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
      Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
      Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
      Regulation of signaling by CBL, organism-specific biosystemCbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl negatively regulates PI3...
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
      Role of phospholipids in phagocytosis, organism-specific biosystemPhospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ25043, FLJ37489, DKFZp313N1010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    Toll-like receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    activation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    beta selection IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to molecule of fungal origin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    leukocyte activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    lymph vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    macrophage activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neutrophil activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-3 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mast cell degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of arachidonic acid secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neutrophil degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin secretion by platelet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    transcription factor import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    B cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IC
    Inferred by Curator
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen tyrosine kinase
    NP_001128524.1
    NP_001167638.1
    NP_001167639.1
    NP_003168.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017046.1 RefSeqGene

      Range
      4951..101831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135052.3NP_001128524.1  tyrosine-protein kinase SYK isoform Syk(S)

      See identical proteins and their annotated locations for NP_001128524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).
      Source sequence(s)
      AL354862, DB458719, W33104, Z29630
      Consensus CDS
      CCDS47992.1
      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R273
      Related
      ENSP00000364904.4, OTTHUMP00000021630, ENST00000375751.8, OTTHUMT00000053021
      Conserved Domains (4) summary
      cd05116
      Location:352608
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:351603
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001174167.2NP_001167638.1  tyrosine-protein kinase SYK isoform Syk(L)

      See identical proteins and their annotated locations for NP_001167638.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform Syk(L).
      Source sequence(s)
      AL354862, BU429809, W33104, X73568
      Consensus CDS
      CCDS6688.1
      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R244
      Related
      ENSP00000364898.1, OTTHUMP00000021628, ENST00000375746.1, OTTHUMT00000053019
      Conserved Domains (4) summary
      cd05116
      Location:375631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:374626
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_001174168.2NP_001167639.1  tyrosine-protein kinase SYK isoform Syk(S)

      See identical proteins and their annotated locations for NP_001167639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).
      Source sequence(s)
      AL354862, BC011399, BM019270, W33104
      Consensus CDS
      CCDS47992.1
      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R273
      Related
      ENSP00000364899.1, OTTHUMP00000021629, ENST00000375747.5, OTTHUMT00000053020
      Conserved Domains (4) summary
      cd05116
      Location:352608
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:351603
      Pkinase_Tyr; Protein tyrosine kinase
    4. NM_003177.6NP_003168.2  tyrosine-protein kinase SYK isoform Syk(L)

      See identical proteins and their annotated locations for NP_003168.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (Syk(L)). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AL354862, BC001645, DB458719, L28824, W33104
      Consensus CDS
      CCDS6688.1
      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R244
      Related
      ENSP00000364907.4, OTTHUMP00000021627, ENST00000375754.8, OTTHUMT00000053018
      Conserved Domains (4) summary
      cd05116
      Location:375631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:374626
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      90801680..90898560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252147.3XP_005252204.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005252204.1

      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R244
      Conserved Domains (4) summary
      cd05116
      Location:375631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:374626
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_011518946.2XP_011517248.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_011517248.1

      UniProtKB/Swiss-Prot
      P43405
      UniProtKB/TrEMBL
      A0A024R244
      Conserved Domains (4) summary
      cd05116
      Location:375631
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:13116
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:164262
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:374626
      Pkinase_Tyr; Protein tyrosine kinase

    RNA

    1. XR_001746370.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      93710434..93807287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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