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    Per3 period circadian clock 3 [ Mus musculus (house mouse) ]

    Gene ID: 18628, updated on 4-Jun-2017
    Official Symbol
    Per3provided by MGI
    Official Full Name
    period circadian clock 3provided by MGI
    Primary source
    MGI:MGI:1277134
    See related
    Ensembl:ENSMUSG00000028957 Vega:OTTMUSG00000010238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPer3; 2810049O06Rik
    Summary
    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
    Orthologs
    Location:
    4; 4 E2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (150997018..151044723, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150377764..150418731, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 9 Neighboring gene predicted gene, 30120 Neighboring gene urotensin 2 Neighboring gene predicted gene, 38529 Neighboring gene vesicle-associated membrane protein 3 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene predicted gene 13090

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    period circadian protein homolog 3
    Names
    circadian clock protein PERIOD 3
    period homolog 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289877.1NP_001276806.1  period circadian protein homolog 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL607143
      Conserved Domains (3) summary
      cd00130
      Location:280372
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:280368
      PAS_3; PAS fold
      pfam12114
      Location:9081111
      Period_C; Period protein 2/3C-terminal region
    2. NM_001289878.1NP_001276807.1  period circadian protein homolog 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL607143
      Conserved Domains (1) summary
      pfam12114
      Location:701797
      Period_C; Period protein 2/3C-terminal region
    3. NM_011067.3NP_035197.2  period circadian protein homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_035197.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AL607143
      Consensus CDS
      CCDS18978.1
      UniProtKB/Swiss-Prot
      O70361
      Related
      ENSMUSP00000099493.4, OTTMUSP00000010897, ENSMUST00000103204.10, OTTMUST00000023794
      Conserved Domains (3) summary
      cd00130
      Location:280372
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:280368
      PAS_3; PAS fold
      pfam12114
      Location:9071110
      Period_C; Period protein 2/3C-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      150997018..151044723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320033.1XP_017175522.1  period circadian protein homolog 3 isoform X3

    2. XM_017320031.1XP_017175520.1  period circadian protein homolog 3 isoform X1

    3. XM_017320032.1XP_017175521.1  period circadian protein homolog 3 isoform X2

    4. XM_017320035.1XP_017175524.1  period circadian protein homolog 3 isoform X6

    5. XM_017320036.1XP_017175525.1  period circadian protein homolog 3 isoform X7

    6. XM_017320034.1XP_017175523.1  period circadian protein homolog 3 isoform X5

    7. XM_011250203.2XP_011248505.1  period circadian protein homolog 3 isoform X4

      Conserved Domains (3) summary
      cd00130
      Location:280372
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:280368
      PAS_3; PAS fold
      pfam12114
      Location:9071110
      Period_C; Period protein 2/3C-terminal region

    RNA

    1. XR_001784108.1 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187025.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1308346..1349365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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