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    FUT9 fucosyltransferase 9 [ Homo sapiens (human) ]

    Gene ID: 10690, updated on 8-Oct-2017
    Official Symbol
    FUT9provided by HGNC
    Official Full Name
    fucosyltransferase 9provided by HGNC
    Primary source
    HGNC:HGNC:4020
    See related
    Ensembl:ENSG00000172461 MIM:606865; Vega:OTTHUMG00000015236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fuc-TIX
    Summary
    The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    6q16.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (96015969..96215612)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96463845..96663488)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986543 Neighboring gene uncharacterized LOC107986626 Neighboring gene keratin 18 pseudogene 50 Neighboring gene uncharacterized LOC105377905 Neighboring gene RNA, 7SL, cytoplasmic 797, pseudogene Neighboring gene uncharacterized LOC105377904

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    fucosylation IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    alpha-(1,3)-fucosyltransferase 9
    Names
    fucT-IX
    fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
    fucosyltransferase IX
    galactoside 3-L-fucosyltransferase
    NP_006572.2
    XP_011533685.1
    XP_011533687.1
    XP_016865677.1
    XP_016865679.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006581.3NP_006572.2  alpha-(1,3)-fucosyltransferase 9

      See identical proteins and their annotated locations for NP_006572.2

      Status: REVIEWED

      Source sequence(s)
      AL512406, BC036101, CK299829, CK904220
      Consensus CDS
      CCDS5033.1
      UniProtKB/Swiss-Prot
      Q9Y231
      Related
      ENSP00000302599.4, OTTHUMP00000016877, ENST00000302103.5, OTTHUMT00000041554
      Conserved Domains (2) summary
      pfam00852
      Location:185354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      96015969..96215612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010190.1XP_016865679.1  alpha-(1,3)-fucosyltransferase 9 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y231
      Conserved Domains (2) summary
      pfam00852
      Location:185354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    2. XM_011535385.2XP_011533687.1  alpha-(1,3)-fucosyltransferase 9 isoform X1

      See identical proteins and their annotated locations for XP_011533687.1

      UniProtKB/Swiss-Prot
      Q9Y231
      Conserved Domains (2) summary
      pfam00852
      Location:185354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    3. XM_011535383.2XP_011533685.1  alpha-(1,3)-fucosyltransferase 9 isoform X1

      See identical proteins and their annotated locations for XP_011533685.1

      UniProtKB/Swiss-Prot
      Q9Y231
      Conserved Domains (2) summary
      pfam00852
      Location:185354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    4. XM_017010188.1XP_016865677.1  alpha-(1,3)-fucosyltransferase 9 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y231
      Conserved Domains (2) summary
      pfam00852
      Location:185354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      96725919..96925506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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