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    Ada adenosine deaminase [ Mus musculus (house mouse) ]

    Gene ID: 11486, updated on 12-Mar-2017
    Official Symbol
    Adaprovided by MGI
    Official Full Name
    adenosine deaminaseprovided by MGI
    Primary source
    MGI:MGI:87916
    See related
    Ensembl:ENSMUSG00000017697 Vega:OTTMUSG00000001154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    2 84.44 cM; 2 H3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (163726571..163750239, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (163552320..163575913, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene protein kinase inhibitor, gamma Neighboring gene uncharacterized LOC102639518 Neighboring gene WNT1 inducible signaling pathway protein 2 Neighboring gene potassium channel, subfamily K, member 15

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    purine nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Peyer's patch development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    dATP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dATP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    deoxyadenosine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deoxyadenosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germinal center B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    hypoxanthine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inosine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mature B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mucus secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of penile erection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    purine nucleotide salvage ISO
    Inferred from Sequence Orthology
    more info
     
    purine ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    response to vitamin E ISO
    Inferred from Sequence Orthology
    more info
     
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xanthine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    adenosine deaminase
    Names
    adenosine aminohydrolase
    NP_001258981.1
    NP_031424.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272052.1NP_001258981.1  adenosine deaminase

      See identical proteins and their annotated locations for NP_001258981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075899, AL591490, D19191
      Consensus CDS
      CCDS17015.1
      UniProtKB/Swiss-Prot
      P03958
      UniProtKB/TrEMBL
      Q4FK28
      Conserved Domains (1) summary
      cd01320
      Location:8336
      ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...
    2. NM_007398.4NP_031424.1  adenosine deaminase

      See identical proteins and their annotated locations for NP_031424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075899, AL591490
      Consensus CDS
      CCDS17015.1
      UniProtKB/Swiss-Prot
      P03958
      UniProtKB/TrEMBL
      Q4FK28
      Related
      ENSMUSP00000017841, OTTMUSP00000001096, ENSMUST00000017841, OTTMUST00000002247
      Conserved Domains (1) summary
      cd01320
      Location:8336
      ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      163726571..163750239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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