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    Ptpn1 protein tyrosine phosphatase, non-receptor type 1 [ Mus musculus (house mouse) ]

    Gene ID: 19246, updated on 7-Jan-2018
    Official Symbol
    Ptpn1provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 1provided by MGI
    Primary source
    MGI:MGI:97805
    See related
    Ensembl:ENSMUSG00000027540 Vega:OTTMUSG00000015956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP1B; PTP-1B; PTP-HA2
    Expression
    Ubiquitous expression in spleen adult (RPKM 41.9), ovary adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    Location:
    2; 2 H3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (167932009..167979385)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (167757827..167804885)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32845 Neighboring gene predicted gene, 33033 Neighboring gene predicted gene, 32928 Neighboring gene RIPOR family member 3 Neighboring gene predicted gene, 33108

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of PERK-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sorting endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 1
    Names
    protein-protein-tyrosine phosphatase HA2
    protein-tyrosine phosphatase 1B
    protein-tyrosine phosphatase HA2
    NP_035331.3
    XP_006499044.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011201.3NP_035331.3  tyrosine-protein phosphatase non-receptor type 1

      See identical proteins and their annotated locations for NP_035331.3

      Status: VALIDATED

      Source sequence(s)
      AL928998
      Consensus CDS
      CCDS17107.1
      UniProtKB/Swiss-Prot
      P35821
      UniProtKB/TrEMBL
      Q3TZW9
      Related
      ENSMUSP00000029053.7, OTTMUSP00000017024, ENSMUST00000029053.7, OTTMUST00000037925
      Conserved Domains (2) summary
      smart00194
      Location:3276
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:43276
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      167932009..167979385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498981.3XP_006499044.1  tyrosine-protein phosphatase non-receptor type 1 isoform X1

      Conserved Domains (2) summary
      smart00194
      Location:5203
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1203
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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