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    Fgf1 fibroblast growth factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25317, updated on 3-Sep-2016
    Official Symbol
    Fgf1provided by RGD
    Official Full Name
    fibroblast growth factor 1provided by RGD
    Primary source
    RGD:2605
    See related
    Ensembl:ENSRNOG00000013867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FGF-1; HBGF1; HBGF-1
    Summary
    may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion [RGD, Feb 2006]
    Orthologs
    Location:
    18p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (32273830..32359831)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (31951411..32037426)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911367 Neighboring gene uncharacterized LOC108348867 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene Rho GTPase activating protein 26 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC108353182 Neighboring gene uncharacterized LOC102547511

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase B activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branch elongation involved in ureteric bud branching ISO
    Inferred from Sequence Orthology
    more info
     
    branch elongation involved in ureteric bud branching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    mesonephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    mesonephric epithelium development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    organ induction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial tube morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor 1
    Names
    Fibroblast growth factor 1 (heparin binding)
    aFGF
    acidic fibroblast growth factor
    fibroblast growth factor 1 (acidic)
    heparin-binding growth factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012846.1NP_036978.1  fibroblast growth factor 1 precursor

      See identical proteins and their annotated locations for NP_036978.1

      Status: PROVISIONAL

      Source sequence(s)
      X14232
      UniProtKB/Swiss-Prot
      P61149
      Related
      ENSRNOP00000018577, ENSRNOT00000018577
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      32273830..32359831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254650.3XP_006254712.1  

      See identical proteins and their annotated locations for XP_006254712.1

      UniProtKB/Swiss-Prot
      P61149
      Related
      ENSRNOP00000070685, ENSRNOT00000087408
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    2. XM_006254652.3XP_006254714.1  

      See identical proteins and their annotated locations for XP_006254714.1

      UniProtKB/Swiss-Prot
      P61149
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    3. XM_006254651.3XP_006254713.1  

      See identical proteins and their annotated locations for XP_006254713.1

      UniProtKB/Swiss-Prot
      P61149
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      30325334..30346306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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