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    MOGS mannosyl-oligosaccharide glucosidase [ Homo sapiens (human) ]

    Gene ID: 7841, updated on 6-Dec-2016
    Official Symbol
    MOGSprovided by HGNC
    Official Full Name
    mannosyl-oligosaccharide glucosidaseprovided by HGNC
    Primary source
    HGNC:HGNC:24862
    See related
    Ensembl:ENSG00000115275 MIM:601336; Vega:OTTHUMG00000152886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DER7; GCS1; CDG2B; CWH41
    Summary
    This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
    Orthologs
    Location:
    2p13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (74461057..74465410, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74688184..74692537, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene INO80B-WBP1 readthrough (NMD candidate) Neighboring gene INO80 complex subunit B Neighboring gene WW domain binding protein 1 Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene coiled-coil domain containing 142 Neighboring gene tetratricopeptide repeat domain 31

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify mannosyl-oligosaccharide glucosidase (MOGS; GCS1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env HIV-1 gp120 is identified to have a physical interaction with glucosidase (GCS1; MOGS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
    env The alpha-glucosidase inhibitor N-butyldeoxynojirimycin (NB-DNJ) inhibits HIV-1 entry and this inhibition correlates with impaired HIV-1 gp120 shedding and gp41 exposure and with changes in antibody recognition of gp120 PubMed
    env Imino sugar N-butyldeoxynojirimycin (NB-DNJ) inhibits HIV envelope glycoprotein gp120 processing mediated by alpha glucosidase I PubMed
    env HIV-1 gp120 is extremely heavily glycosylated (31-36 N-linked glycans per molecule) by glucosidase PubMed
    env Glucosidase inhibitors inhibit the syncytium formation between HIV-infected and CD4-expressing cells and interfere with HIV-1 infectivity, indicating processing of HIV-1 gp120 by glucosidase is important for virus replication PubMed
    Envelope surface glycoprotein gp160, precursor env Inhibitors of alpha-glucosidase inhibit syncytium formation induced by the envelope glycoprotein of HIV-1 and reduce processing of the HIV-1 envelope precursor protein gp160 by glucosidase PubMed
    env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
    Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify mannosyl-oligosaccharide glucosidase (MOGS; GCS1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify mannosyl-oligosaccharide glucosidase (MOGS; GCS1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify mannosyl-oligosaccharide glucosidase (MOGS; GCS1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with mannosyl-oligosaccharide glucosidase (MOGS; GCS1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glucosidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    mannosyl-oligosaccharide glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mannosyl-oligosaccharide glucosidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-linked glycosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mannosyl-oligosaccharide glucosidase
    Names
    glucosidase I
    processing A-glucosidase I
    NP_001139630.1
    NP_006293.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008922.1 RefSeqGene

      Range
      5001..9354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001146158.1NP_001139630.1  mannosyl-oligosaccharide glucosidase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment that includes the translation start site compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to variant 1.
      Source sequence(s)
      AA292430, BC028337, BC117250, DA520534, DC388420
      Consensus CDS
      CCDS54370.1
      UniProtKB/Swiss-Prot
      Q13724
      UniProtKB/TrEMBL
      Q58F09
      Related
      ENSP00000388201, ENST00000452063
      Conserved Domains (2) summary
      pfam03200
      Location:246729
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:1181
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
    2. NM_006302.2NP_006293.2  mannosyl-oligosaccharide glucosidase isoform 1

      See identical proteins and their annotated locations for NP_006293.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA292430, BC117252, DC402060
      Consensus CDS
      CCDS42700.1
      UniProtKB/Swiss-Prot
      Q13724
      Related
      ENSP00000233616, OTTHUMP00000202621, ENST00000233616, OTTHUMT00000328382
      Conserved Domains (2) summary
      pfam03200
      Location:352835
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:94287
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      74461057..74465410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004877.1XP_016860366.1  

    2. XM_017004876.1XP_016860365.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      74617601..74621954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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