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    CD1C CD1c molecule [ Homo sapiens (human) ]

    Gene ID: 911, updated on 3-Sep-2017
    Official Symbol
    CD1Cprovided by HGNC
    Official Full Name
    CD1c moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1636
    See related
    Ensembl:ENSG00000158481 MIM:188340; Vega:OTTHUMG00000017514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R7; CD1; CD1A; BDCA1
    Summary
    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 8.6), appendix (RPKM 6.9) and 15 other tissues See more
    Orthologs
    Location:
    1q23.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (158289773..158294774)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158259563..158264564)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD1a molecule Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 5 Neighboring gene CD1b molecule Neighboring gene CD1e molecule Neighboring gene olfactory receptor family 10 subfamily T member 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu downregulates CD1c in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-2-microglobulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endogenous lipid antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exogenous lipid antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    T-cell surface glycoprotein CD1c
    Names
    CD1C antigen, c polypeptide
    cortical thymocyte antigen CD1C
    differentiation antigen CD1-alpha-3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001765.2NP_001756.2  T-cell surface glycoprotein CD1c precursor

      See identical proteins and their annotated locations for NP_001756.2

      Status: REVIEWED

      Source sequence(s)
      AA824381, AL121986, M28827
      Consensus CDS
      CCDS1175.1
      UniProtKB/Swiss-Prot
      P29017
      Related
      ENSP00000357152.3, OTTHUMP00000018909, ENST00000368170.7, OTTHUMT00000046351
      Conserved Domains (2) summary
      cd07698
      Location:204296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:20197
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      158289773..158294774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245579.4XP_005245636.1  T-cell surface glycoprotein CD1c isoform X1

      Related
      ENSP00000408755.1, OTTHUMP00000035066, ENST00000443761.1, OTTHUMT00000089861
      Conserved Domains (2) summary
      cd07698
      Location:204297
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:20197
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      159655942..159660943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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