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    APC APC, WNT signaling pathway regulator [ Homo sapiens (human) ]

    Gene ID: 324, updated on 23-Sep-2017
    Official Symbol
    APCprovided by HGNC
    Official Full Name
    APC, WNT signaling pathway regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:583
    See related
    Ensembl:ENSG00000134982 MIM:611731; Vega:OTTHUMG00000128806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
    Summary
    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q22.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (112707505..112846239)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112043202..112181936)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2200 Neighboring gene uncharacterized LOC102467216 Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene chromobox 3 pseudogene 3 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in APC that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Carcinoma of colon
    MedGen: C0699790 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Desmoid disease, hereditary
    MedGen: C1851124 OMIM: 135290 GeneReviews: Not available
    Compare labs
    Familial adenomatous polyposis 1 Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Neoplasm of stomach
    MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2012-07-06)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2012-07-06)

    ClinGen Genome Curation PagePubMed
    • AMER1 mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      AMER1 mutants destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a component of the destruction complex that interacts directly with beta-catenin through its C-terminal half. Depletion of AMER1 through siRNA stabilizes cellular beta-catenin levels an...
    • APC truncation mutants are not K63 polyubiquitinated, organism-specific biosystem (from REACTOME)
      APC truncation mutants are not K63 polyubiquitinated, organism-specific biosystemAPC has been shown to be reversibly modified with K63-linked polyubiquitin chains. This modification is required for the association is required for the assembly of the destruction complex and subse...
    • APC truncation mutants have impaired AXIN binding, organism-specific biosystem (from REACTOME)
      APC truncation mutants have impaired AXIN binding, organism-specific biosystemMutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, ...
    • AXIN missense mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      AXIN missense mutants destabilize the destruction complex, organism-specific biosystemAlterations in AXIN1 have been detected in a number of different cancers including liver and colorectal cancer and medullablastoma, among others (reviewed in Salahshor and Woodgett, 2005). Missense ...
    • AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystem (from REACTOME)
      AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystemAXIN1 and AXIN2 are critical scaffolding proteins of the beta-catenin destruction complex and make protein-protein interactions with several of the other complex components including APC, GSK3, CK1 a...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
      Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Cell Cycle, organism-specific biosystem (from WikiPathways)
      Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Copper homeostasis, organism-specific biosystem (from WikiPathways)
      Copper homeostasis, organism-specific biosystemCopper is a redox-active transition metal and an essential trace element for life. It is a catalytic cofactor for numerous enzymes involved in critical biological processes (eg. detoxyfication by oxy...
    • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
      Deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
      Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemUpon stimulation with WNT ligand, AXIN and GSK3beta are recruited to the plasma membrane through interaction with DVL (Tamai et al, 2004; Mao et al, 2001; reviewed in He et al, 2004). Polymerization...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystem (from WikiPathways)
      Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystemProtein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptor...
    • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
      Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
      Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystem (from REACTOME)
      Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystemGSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show e...
    • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
      Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystem (from WikiPathways)
      Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystemThe Wnt/B-catenin pathway begins with Wnt family activation by MBOAT that allows Wnt proteins to translocate out of a cell and bind to FZD and LRP to form a complex. This complex stimulates B-catenin...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999;...
    • S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis,...
    • S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish th...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by WNT in cancer, organism-specific biosystem (from REACTOME)
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    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemT41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Pol...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • Truncations of AMER1 destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      Truncations of AMER1 destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabil...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway Netpath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway Netpath, organism-specific biosystemWNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, ...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystem (from WikiPathways)
      Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystemThe Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-C...
    • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystem (from REACTOME)
      phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystemMutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations g...
    • truncated APC mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      truncated APC mutants destabilize the destruction complex, organism-specific biosystemAPC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts wi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: SRP19

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    beta-catenin destruction complex assembly TAS
    Traceable Author Statement
    more info
     
    beta-catenin destruction complex disassembly TAS
    Traceable Author Statement
    more info
     
    bicellular tight junction assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    execution phase of apoptosis TAS
    Traceable Author Statement
    more info
     
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of pseudopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
     
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Wnt signalosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    adenomatous polyposis coli protein
    Names
    WNT signaling pathway regulator
    adenomatosis polyposis coli tumor suppressor
    deleted in polyposis 2.5
    protein phosphatase 1, regulatory subunit 46
    truncated adenomatosis polyposis coli

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008481.4 RefSeqGene

      Range
      19985..158719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

    mRNA and Protein(s)

    1. NM_000038.5NP_000029.2  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_000029.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663, M73548
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000257430.4, OTTHUMP00000159019, ENST00000257430.8, OTTHUMT00000250738
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    2. NM_001127510.2NP_001120982.1  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_001120982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000427089.2, OTTHUMP00000222841, ENST00000508376.6, OTTHUMT00000370794
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    3. NM_001127511.2NP_001120983.2  adenomatous polyposis coli protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a).
      Source sequence(s)
      AB210001, AK294544, BP230350, CA313732
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Conserved Domains (13) summary
      cd00020
      Location:593713
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16191643
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20162035
      SAMP; SAMP Motif
      pfam05937
      Location:26522825
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22052550
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7141001
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10181117
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12651350
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16441700
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17211821
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18581929
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:447490
      ARM; armadillo repeat [structural motif]
    4. NM_001354895.1NP_001341824.1  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    5. NM_001354896.1NP_001341825.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (17) summary
      smart00185
      Location:667707
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:709749
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:581613
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16551678
      APC_r; APC repeat
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam05937
      Location:26882861
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7501036
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10541153
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:13011386
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16801733
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17641857
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18911965
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:13091719
      DUF4045; Domain of unknown function (DUF4045)
    6. NM_001354897.1NP_001341826.1  adenomatous polyposis coli protein isoform d

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:659699
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:701741
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:475518
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16471670
      APC_r; APC repeat
      pfam05924
      Location:20432062
      SAMP; SAMP Motif
      pfam05937
      Location:26802853
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22332578
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7421028
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10461145
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12931378
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16721725
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17561849
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18831957
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:13011711
      DUF4045; Domain of unknown function (DUF4045)
    7. NM_001354898.1NP_001341827.1  adenomatous polyposis coli protein isoform e

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:624664
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:666706
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:440483
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16121635
      APC_r; APC repeat
      pfam05924
      Location:20082027
      SAMP; SAMP Motif
      pfam05937
      Location:26452818
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21982543
      APC_basic; APC basic domain
      pfam11414
      Location:102182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:707993
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10111110
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12581343
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16371690
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17211814
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18481922
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12661676
      DUF4045; Domain of unknown function (DUF4045)
    8. NM_001354899.1NP_001341828.1  adenomatous polyposis coli protein isoform f

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (16) summary
      smart00185
      Location:621661
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:663703
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:437480
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16091632
      APC_r; APC repeat
      pfam05924
      Location:20052024
      SAMP; SAMP Motif
      pfam05937
      Location:26422815
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21952540
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:704990
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10081107
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12551340
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16341687
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17181811
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18451919
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12631673
      DUF4045; Domain of unknown function (DUF4045)
    9. NM_001354900.1NP_001341829.1  adenomatous polyposis coli protein isoform g

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:608648
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:650690
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:522554
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15961619
      APC_r; APC repeat
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292802
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:691977
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9951094
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12421327
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16211674
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17051798
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18321906
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12501660
      DUF4045; Domain of unknown function (DUF4045)
    10. NM_001354901.1NP_001341830.1  adenomatous polyposis coli protein isoform h

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:590630
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:632672
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:406449
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15781601
      APC_r; APC repeat
      pfam05924
      Location:19741993
      SAMP; SAMP Motif
      pfam05937
      Location:26112784
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21642509
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:673959
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9771076
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12241309
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16031656
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16871780
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18141888
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12321642
      DUF4045; Domain of unknown function (DUF4045)
    11. NM_001354902.1NP_001341831.1  adenomatous polyposis coli protein isoform i

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:558598
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:600640
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:374417
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15461569
      APC_r; APC repeat
      pfam05924
      Location:19421961
      SAMP; SAMP Motif
      pfam05937
      Location:25792752
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21322477
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:641927
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9451044
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11921277
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15711624
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16551748
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17821856
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12001610
      DUF4045; Domain of unknown function (DUF4045)
    12. NM_001354903.1NP_001341832.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (17) summary
      smart00185
      Location:548588
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:590630
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:364407
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15361559
      APC_r; APC repeat
      pfam05924
      Location:19321951
      SAMP; SAMP Motif
      pfam05937
      Location:25692742
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21222467
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:631917
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9351034
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11821267
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15611614
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16451738
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17721846
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:11901600
      DUF4045; Domain of unknown function (DUF4045)
    13. NM_001354904.1NP_001341833.1  adenomatous polyposis coli protein isoform k

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:523563
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:565605
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:339382
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15111534
      APC_r; APC repeat
      pfam05924
      Location:19071926
      SAMP; SAMP Motif
      pfam05937
      Location:25442717
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:20972442
      APC_basic; APC basic domain
      pfam11414
      Location:102182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:606892
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9101009
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11571242
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15361589
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16201713
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17471821
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:11651575
      DUF4045; Domain of unknown function (DUF4045)
    14. NM_001354905.1NP_001341834.1  adenomatous polyposis coli protein isoform l

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:489529
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:531571
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:305348
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:14771500
      APC_r; APC repeat
      pfam05924
      Location:18731892
      SAMP; SAMP Motif
      pfam05937
      Location:25102683
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:20632408
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:572858
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:876975
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11231208
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15021555
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:15861679
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17131787
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:11311541
      DUF4045; Domain of unknown function (DUF4045)
    15. NM_001354906.1NP_001341835.1  adenomatous polyposis coli protein isoform m

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (14) summary
      smart00185
      Location:366406
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:408448
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:182225
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:13541377
      APC_r; APC repeat
      pfam05924
      Location:17501769
      SAMP; SAMP Motif
      pfam05937
      Location:23872560
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:19402285
      APC_basic; APC basic domain
      pfam16629
      Location:449735
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:753852
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:10001085
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:13791432
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:14631556
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:15901664
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:10081418
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      112707505..112846239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      111476576..111615241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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