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    Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Mus musculus (house mouse) ]

    Gene ID: 30955, updated on 13-Dec-2017
    Official Symbol
    Pik3cgprovided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by MGI
    Primary source
    MGI:MGI:1353576
    See related
    Ensembl:ENSMUSG00000020573 Vega:OTTMUSG00000033083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI3Kgamma; p110gamma; 5830428L06Rik
    Expression
    Biased expression in thymus adult (RPKM 8.2), spleen adult (RPKM 4.8) and 13 other tissues See more
    Orthologs
    Location:
    12; 12 A3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (32173129..32208677, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32858262..32893514, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430401H09 gene Neighboring gene predicted gene, 40374 Neighboring gene predicted gene, 33308 Neighboring gene coiled-coil domain containing 71 like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cAMP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretory granule localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase complex, class IB IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase complex, class IB ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Names
    PI3-kinase subunit gamma
    PI3K-gamma
    p120-PI3K
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
    phosphoinositide-3-kinase, catalytic, gamma polypeptide
    ptdIns-3-kinase subunit gamma
    ptdIns-3-kinase subunit p110-gamma
    serine/threonine protein kinase PIK3CG
    NP_001139672.1
    NP_001139673.1
    NP_064668.2
    XP_006515175.1
    XP_006515176.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146200.1NP_001139672.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_001139672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC140314, AK077772, AK137470
      Consensus CDS
      CCDS25870.1
      UniProtKB/Swiss-Prot
      Q9JHG7
      UniProtKB/TrEMBL
      Q3UVA4, Q8C5Q7
      Related
      ENSMUSP00000062864.7, OTTMUSP00000044316, ENSMUST00000053215.13, OTTMUST00000082636
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    2. NM_001146201.1NP_001139673.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_001139673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC140314, AK077772, AK137470
      Consensus CDS
      CCDS25870.1
      UniProtKB/Swiss-Prot
      Q9JHG7
      UniProtKB/TrEMBL
      Q3UVA4, Q8C5Q7
      Related
      ENSMUSP00000151400.1, ENSMUST00000220366.1
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    3. NM_020272.2NP_064668.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_064668.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC140314, AK077772, AK137470
      Consensus CDS
      CCDS25870.1
      UniProtKB/Swiss-Prot
      Q9JHG7
      UniProtKB/TrEMBL
      Q3UVA4, Q8C5Q7
      Related
      ENSMUSP00000082596.5, OTTMUSP00000044317, ENSMUST00000085469.5, OTTMUST00000082637
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      32173129..32208677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515112.3XP_006515175.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_006515175.1

      UniProtKB/Swiss-Prot
      Q9JHG7
      Related
      ENSMUSP00000152007.1, ENSMUST00000217915.1
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    2. XM_006515113.3XP_006515176.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cl21453
      Location:7291010
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_872416.1 RNA Sequence

    2. XR_001780451.1 RNA Sequence

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