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    BECN1 beclin 1 [ Homo sapiens (human) ]

    Gene ID: 8678, updated on 21-May-2017
    Official Symbol
    BECN1provided by HGNC
    Official Full Name
    beclin 1provided by HGNC
    Primary source
    HGNC:HGNC:1034
    See related
    Ensembl:ENSG00000126581 MIM:604378; Vega:OTTHUMG00000180653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG6; VPS30; beclin1
    Summary
    This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    17q21.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (42810132..42824316, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40962150..40976310, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene uncharacterized LOC107985007 Neighboring gene microRNA 6781 Neighboring gene proteasome activator subunit 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Asp asp HIV-1 ASP expression upregulates the levels of two autophagy markers, LC3b and Beclin 1 in COS-7 cells, suggesting ASP activates autophagy in mammalian cells PubMed
    Envelope surface glycoprotein gp120 env HIV-1 Env gp120 treatment of SH-SY5Y cells increases BECN1 which indicates the initiation of autophagosome formation PubMed
    Nef nef HIV-1 Nef directly interacts with Beclin-1 to inhibit autophagy in human mesenchymal stem cells PubMed
    nef Genome-wide shRNA screening identifies BECN1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    nef HIV-1 Nef acts as an antiautophagic maturation factor through interaction with the autophagy regulatory factor Beclin 1, leading to protect HIV-1 from degradation PubMed
    capsid gag Knockdown of Beclin 1 (ATG6) results in diminished levels of p24 yields in both primary monocyte- and U937-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Nanoparticle triggered autophagic cell death, organism-specific biosystem (from WikiPathways)
      Nanoparticle triggered autophagic cell death, organism-specific biosystemProgrammed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can re...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT CVT pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-amyloid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    engulfment of apoptotic cell IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macroautophagy TAS
    Traceable Author Statement
    more info
     
    macromitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron(II) ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to mitochondrial depolarisation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase complex, class III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    pre-autophagosomal structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    beclin-1
    Names
    ATG6 autophagy related 6 homolog
    beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
    beclin 1, autophagy related
    coiled-coil myosin-like BCL2-interacting protein
    testis secretory sperm-binding protein Li 215e

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313998.1NP_001300927.1  beclin-1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AA427906, AC016889, AK312651, BC010276, DC354547
      Consensus CDS
      CCDS11441.1
      UniProtKB/Swiss-Prot
      Q14457
      UniProtKB/TrEMBL
      A0A024R1X5
      Related
      ENSP00000465364.1, OTTHUMP00000264883, ENST00000590099.5, OTTHUMT00000452407
      Conserved Domains (3) summary
      pfam04111
      Location:135446
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    2. NM_001313999.1NP_001300928.1  beclin-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isoform a.
      Source sequence(s)
      AA427906, BC010276, KC776730
      UniProtKB/Swiss-Prot
      Q14457
      UniProtKB/TrEMBL
      W0FFG4
      Conserved Domains (3) summary
      pfam04111
      Location:135348
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    3. NM_001314000.1NP_001300929.1  beclin-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus, and is shorter than isoform a.
      Source sequence(s)
      AA427906, AC016889, AK298619, BC010276, DC354547
      Consensus CDS
      CCDS82132.1
      UniProtKB/Swiss-Prot
      Q14457
      UniProtKB/TrEMBL
      B4DQ36, E7EV84
      Related
      ENSP00000416173.2, OTTHUMP00000264885, ENST00000438274.7, OTTHUMT00000452409
      Conserved Domains (2) summary
      pfam04111
      Location:87272
      APG6; Autophagy protein Apg6
      pfam12777
      Location:120193
      MT; Microtubule-binding stalk of dynein motor
    4. NM_003766.4NP_003757.1  beclin-1 isoform a

      See identical proteins and their annotated locations for NP_003757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA427906, BC010276, DC354547
      Consensus CDS
      CCDS11441.1
      UniProtKB/Swiss-Prot
      Q14457
      UniProtKB/TrEMBL
      A0A024R1X5
      Related
      ENSP00000355231.3, OTTHUMP00000264882, ENST00000361523.8, OTTHUMT00000452405
      Conserved Domains (3) summary
      pfam04111
      Location:135446
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      42810132..42824316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025263.1XP_016880752.1  beclin-1 isoform X2

      Conserved Domains (3) summary
      pfam04111
      Location:135378
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    2. XM_017025262.1XP_016880751.1  beclin-1 isoform X1

      Conserved Domains (4) summary
      pfam04111
      Location:135348
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam13900
      Location:347388
      GVQW; Putative domain of unknown function
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    3. XM_005257759.2XP_005257816.1  beclin-1 isoform X2

      Conserved Domains (3) summary
      pfam04111
      Location:135378
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    4. XM_011525421.2XP_011523723.1  beclin-1 isoform X1

      Conserved Domains (4) summary
      pfam04111
      Location:135348
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam13900
      Location:347388
      GVQW; Putative domain of unknown function
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    5. XM_017025264.1XP_016880753.1  beclin-1 isoform X3

      UniProtKB/TrEMBL
      W0FFG4
      Conserved Domains (3) summary
      pfam04111
      Location:135348
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    6. XM_005257760.3XP_005257817.1  beclin-1 isoform X3

      See identical proteins and their annotated locations for XP_005257817.1

      UniProtKB/TrEMBL
      W0FFG4
      Conserved Domains (3) summary
      pfam04111
      Location:135348
      APG6; Autophagy protein Apg6
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam15285
      Location:107129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      41197767..41211946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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