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    Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 14394, updated on 22-Apr-2017
    Official Symbol
    Gabra1provided by MGI
    Official Full Name
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1provided by MGI
    Primary source
    MGI:MGI:95613
    See related
    Ensembl:ENSMUSG00000010803 Vega:OTTMUSG00000005445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gabra-1
    Orthologs
    Location:
    11 A5; 11 24.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (42130939..42183380, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (41944982..41996432, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12142 Neighboring gene uncharacterized LOC102637814 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 Neighboring gene predicted gene, 34591 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit beta 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GABA-gated chloride ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular ligand-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to histamine ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission, postsynaptic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    GABA receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GABA-A receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-1
    Names
    GABA(A) receptor subunit alpha-1
    GABAA alpha 1
    GABAAR alpha1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010250.5NP_034380.1  gamma-aminobutyric acid receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_034380.1

      Status: VALIDATED

      Source sequence(s)
      AK034095, AK141596, BC137733, BE945884
      Consensus CDS
      CCDS24553.1
      UniProtKB/Swiss-Prot
      P62812
      UniProtKB/TrEMBL
      Q3URD4, Q544F7
      Related
      ENSMUSP00000020707.5, OTTMUSP00000005606, ENSMUST00000020707.11, OTTMUST00000012129
      Conserved Domains (3) summary
      TIGR00860
      Location:7441
      LIC; Cation transporter family protein
      pfam02931
      Location:42249
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:256438
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      42130939..42183380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314260.1XP_017169749.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      UniProtKB/Swiss-Prot
      P62812
      UniProtKB/TrEMBL
      Q544F7
      Conserved Domains (3) summary
      TIGR00860
      Location:7441
      LIC; Cation transporter family protein
      pfam02931
      Location:42249
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:256438
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. XM_017314259.1XP_017169748.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      UniProtKB/Swiss-Prot
      P62812
      UniProtKB/TrEMBL
      Q544F7
      Conserved Domains (3) summary
      TIGR00860
      Location:7441
      LIC; Cation transporter family protein
      pfam02931
      Location:42249
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:256438
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    3. XM_006532195.3XP_006532258.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X1

      Conserved Domains (3) summary
      TIGR00860
      Location:105539
      LIC; Cation transporter family protein
      pfam02931
      Location:140347
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:354536
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    4. XM_006532196.3XP_006532259.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      See identical proteins and their annotated locations for XP_006532259.1

      UniProtKB/Swiss-Prot
      P62812
      UniProtKB/TrEMBL
      Q544F7
      Related
      ENSMUSP00000146133.1, OTTMUSP00000049803, ENSMUST00000205546.1, OTTMUST00000012130
      Conserved Domains (3) summary
      TIGR00860
      Location:7441
      LIC; Cation transporter family protein
      pfam02931
      Location:42249
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:256438
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
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