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    Ctsc cathepsin C [ Mus musculus (house mouse) ]

    Gene ID: 13032, updated on 27-Jan-2018
    Official Symbol
    Ctscprovided by MGI
    Official Full Name
    cathepsin Cprovided by MGI
    Primary source
    MGI:MGI:109553
    See related
    Ensembl:ENSMUSG00000030560 Vega:OTTMUSG00000031137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CatC; DPP1; DPPI; AI047818
    Summary
    This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.0), mammary gland adult (RPKM 4.8) and 22 other tissues See more
    Orthologs
    Location:
    7; 7 D3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (88278023..88315861)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (95426603..95459385)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene tyrosinase Neighboring gene glutamate receptor, metabotropic 5 Neighboring gene splicing factor 3a, subunit 1 pseudogene Neighboring gene predicted gene 2407 Neighboring gene RAB38, member RAS oncogene family

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activator activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell mediated cytotoxicity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis involved in cellular protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dipeptidyl peptidase 1
    Names
    cathepsin J
    dipeptidyl peptidase I
    dipeptidyl transferase
    NP_001298719.1
    NP_034112.3
    XP_006507383.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311790.1NP_001298719.1  dipeptidyl peptidase 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.
      Source sequence(s)
      AC124322, AK146858, AK152524, AV367948, BQ561752, BY381435, CN722521
      Consensus CDS
      CCDS85332.1
      UniProtKB/TrEMBL
      Q3U7T5, Q3UBY5
      Related
      ENSMUSP00000147006.1, OTTMUSP00000076041, ENSMUST00000131108.8, OTTMUST00000077134
      Conserved Domains (1) summary
      pfam08773
      Location:26106
      CathepsinC_exc; Cathepsin C exclusion domain
    2. NM_009982.5NP_034112.3  dipeptidyl peptidase 1 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034112.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124322, AC164000, AK049406, AK142945, AK146858, AK150761
      Consensus CDS
      CCDS21438.1
      UniProtKB/Swiss-Prot
      P97821
      UniProtKB/TrEMBL
      Q3UBY5, Q8BQL3
      Related
      ENSMUSP00000032779.5, OTTMUSP00000040719, ENSMUST00000032779.11, OTTMUST00000077133
      Conserved Domains (3) summary
      cd02621
      Location:230459
      Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
      pfam04595
      Location:168204
      Pox_I6; Poxvirus I6-like family
      pfam08773
      Location:26138
      CathepsinC_exc; Cathepsin C exclusion domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      88278023..88315861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507320.3XP_006507383.1  dipeptidyl peptidase 1 isoform X1

      Conserved Domains (1) summary
      pfam08773
      Location:26106
      CathepsinC_exc; Cathepsin C exclusion domain
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