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    ple pale [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38746, updated on 9-Apr-2017
    Official Symbol
    pleprovided by FlyBase
    Official Full Name
    paleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005626
    Locus tag
    Dmel_CG10118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10118; DH65B; Dmel\CG10118; DTH; dTH1; dTH65B; Pale; pale/ple; Ple; th; Th; TH; VII
    Location:
    65C3-65C3; 3-18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6713356..6719525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6706456..6712625, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CG10121 gene product from transcript CG10121-RC Neighboring gene CG8519 gene product from transcript CG8519-RA Neighboring gene ncRNA Neighboring gene ncRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine 3-monooxygenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    tyrosine 3-monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adult chitin-containing cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aromatic amino acid family metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    catecholamine metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    courtship behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental pigmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    dopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of adult chitin-containing cuticle pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of adult chitin-containing cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    CG10118 gene product from transcript CG10118-RC
    Names
    CG10118-PA
    CG10118-PB
    CG10118-PC
    Tyrosine-3-hydroxylase
    XBB70 group VII
    drosophila tyrosine hydroxylase
    pale
    ple-PA
    ple-PB
    ple-PC
    tyrosine hydrodroxylase
    tyrosine hydroxylase
    tyrosine-hydroxylase
    tyrosone hydroxylase
    NP_001286955.1
    NP_476897.1
    NP_476898.1

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6713356..6719525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300026.1NP_001286955.1  pale, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459
      UniProtKB/TrEMBL
      B5X0J4
      Related
      FBpp0311654, FBtr0345585
      Conserved Domains (3) summary
      TIGR01269
      Location:130576
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      pfam00351
      Location:243573
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      cl09141
      Location:130234
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
    2. NM_057549.3NP_476897.1  pale, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459
      Related
      FBpp0076665, FBtr0076956
      Conserved Domains (3) summary
      TIGR01269
      Location:48505
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      cd04930
      Location:48163
      ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
      pfam00351
      Location:172502
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    3. NM_057550.4NP_476898.1  pale, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18459
      UniProtKB/TrEMBL
      B5X0J4
      Related
      FBpp0076666, FBtr0076957
      Conserved Domains (3) summary
      TIGR01269
      Location:130576
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      pfam00351
      Location:243573
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      cl09141
      Location:130234
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
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