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    CLIP1 CAP-Gly domain containing linker protein 1 [ Homo sapiens (human) ]

    Gene ID: 6249, updated on 5-Nov-2017
    Official Symbol
    CLIP1provided by HGNC
    Official Full Name
    CAP-Gly domain containing linker protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10461
    See related
    Ensembl:ENSG00000130779 MIM:179838; Vega:OTTHUMG00000168922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSN; CLIP; CYLN1; CLIP170; CLIP-170
    Summary
    The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 36.8), esophagus (RPKM 33.7) and 25 other tissues See more
    Orthologs
    Location:
    12q24.31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (122271432..122422956, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122755981..122907179, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101593348 Neighboring gene diablo IAP-binding mitochondrial protein Neighboring gene VPS33A, CORVET/HOPS core subunit Neighboring gene coiled-coil domain containing 150 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 1 Neighboring gene CLIP1 antisense RNA 1 Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene arginine and serine rich coiled-coil 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
      Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
      Lissencephaly gene (LIS1) in neuronal migration and development
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • RHO GTPases activate IQGAPs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate IQGAPs, organism-specific biosystemIQGAPs constitute a family of scaffolding proteins characterized by a calponin homology (CH) domain, a polyproline binding region (WW domain), a tandem of four IQ (isoleucine and glutamine-rich) repe...
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC131604

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport into plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    intermediate filament TAS
    Traceable Author Statement
    more info
    PubMed 
    kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    colocalizes_with macropinosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    CAP-Gly domain-containing linker protein 1
    Names
    cytoplasmic linker protein 1
    cytoplasmic linker protein 170 alpha-2
    cytoplasmic linker protein CLIP-170
    restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030352.1 RefSeqGene

      Range
      5001..156136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001247997.1NP_001234926.1  CAP-Gly domain-containing linker protein 1 isoform c

      See identical proteins and their annotated locations for NP_001234926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC048338, BC126305, CB305431, M97501
      Consensus CDS
      CCDS58285.1
      UniProtKB/Swiss-Prot
      P30622
      Related
      ENSP00000479322.1, ENST00000620786.4
      Conserved Domains (5) summary
      COG5244
      Location:212812
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:567666
      TMPIT; TMPIT-like protein
      pfam10174
      Location:4741255
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:14161432
      CLIP1_ZNF; CLIP1 zinc knuckle
    2. NM_002956.2NP_002947.1  CAP-Gly domain-containing linker protein 1 isoform a

      See identical proteins and their annotated locations for NP_002947.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AK126990, BM998166, M97501, X64838
      Consensus CDS
      CCDS9232.1
      UniProtKB/Swiss-Prot
      P30622
      UniProtKB/TrEMBL
      A0A024RBR1, B3KXA5
      Related
      ENSP00000351665.2, ENST00000358808.6
      Conserved Domains (4) summary
      TIGR04523
      Location:4291147
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:556655
      TMPIT; TMPIT-like protein
      pfam16641
      Location:14051421
      CLIP1_ZNF; CLIP1 zinc knuckle
    3. NM_198240.1NP_937883.1  CAP-Gly domain-containing linker protein 1 isoform b

      See identical proteins and their annotated locations for NP_937883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AK126990, BM998166, M97501, X64838
      Consensus CDS
      CCDS9233.1
      UniProtKB/Swiss-Prot
      P30622
      UniProtKB/TrEMBL
      B3KXA5
      Related
      ENSP00000445531.1, OTTHUMP00000239759, ENST00000537178.5, OTTHUMT00000401620
      Conserved Domains (5) summary
      COG1196
      Location:6091250
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:212866
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:521620
      TMPIT; TMPIT-like protein
      pfam16641
      Location:13701386
      CLIP1_ZNF; CLIP1 zinc knuckle

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      122271432..122422956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019790.1XP_016875279.1  CAP-Gly domain-containing linker protein 1 isoform X6

      UniProtKB/Swiss-Prot
      P30622
      Conserved Domains (5) summary
      COG1196
      Location:6091250
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5244
      Location:212866
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:521620
      TMPIT; TMPIT-like protein
      pfam16641
      Location:13701386
      CLIP1_ZNF; CLIP1 zinc knuckle
    2. XM_017019792.1XP_016875281.1  CAP-Gly domain-containing linker protein 1 isoform X8

    3. XM_017019788.1XP_016875277.1  CAP-Gly domain-containing linker protein 1 isoform X5

    4. XM_017019791.1XP_016875280.1  CAP-Gly domain-containing linker protein 1 isoform X7

    5. XM_006719552.3XP_006719615.1  CAP-Gly domain-containing linker protein 1 isoform X2

      Conserved Domains (4) summary
      TIGR04523
      Location:4291147
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:556655
      TMPIT; TMPIT-like protein
      pfam16641
      Location:14071423
      CLIP1_ZNF; CLIP1 zinc knuckle
    6. XM_017019787.1XP_016875276.1  CAP-Gly domain-containing linker protein 1 isoform X4

    7. XM_005253593.2XP_005253650.1  CAP-Gly domain-containing linker protein 1 isoform X1

      Conserved Domains (5) summary
      COG5244
      Location:212812
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:567666
      TMPIT; TMPIT-like protein
      pfam10174
      Location:4741255
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16641
      Location:14181434
      CLIP1_ZNF; CLIP1 zinc knuckle
    8. XM_017019786.1XP_016875275.1  CAP-Gly domain-containing linker protein 1 isoform X3

      UniProtKB/Swiss-Prot
      P30622
      UniProtKB/TrEMBL
      A0A024RBR1
      Conserved Domains (4) summary
      TIGR04523
      Location:4291147
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:215278
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:556655
      TMPIT; TMPIT-like protein
      pfam16641
      Location:14051421
      CLIP1_ZNF; CLIP1 zinc knuckle
    9. XM_017019789.1XP_016875278.1  CAP-Gly domain-containing linker protein 1 isoform X5

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      122724274..122875405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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