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    NTRK3 neurotrophic receptor tyrosine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 4916, updated on 8-Nov-2017
    Official Symbol
    NTRK3provided by HGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:8033
    See related
    Ensembl:ENSG00000140538 MIM:191316; Vega:OTTHUMG00000148677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRKC; GP145-TrkC; gp145(trkC)
    Summary
    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
    Orthologs
    Location:
    15q25.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (87859749..88256796, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (88419948..88800026, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724465 Neighboring gene RNA, U6 small nuclear 185, pseudogene Neighboring gene long intergenic non-protein coding RNA 52 Neighboring gene mediator complex subunit 28 pseudogene 6 Neighboring gene uncharacterized LOC105370957 Neighboring gene NTRK3 antisense RNA 1 Neighboring gene uncharacterized LOC105370958

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation.
    NHGRI GWA Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

    Go to the HIV-1, Human Interaction Database

    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
      Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
    • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
      Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    neurotrophin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens fiber cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mechanoreceptor differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    modulation by virus of host transcription IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension involved in regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    NT-3 growth factor receptor
    Names
    ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
    ETV6-NTRK3 fusion
    neurotrophic tyrosine kinase, receptor, type 3
    tyrosine kinase receptor C
    NP_001007157.1
    NP_001012338.1
    NP_001230030.1
    NP_001307063.1
    NP_001307064.1
    NP_002521.2
    XP_006720606.1
    XP_006720607.1
    XP_006720608.1
    XP_006720611.1
    XP_006720612.1
    XP_006720613.1
    XP_011519939.1
    XP_011519940.1
    XP_016877729.1
    XP_016877730.1
    XP_016877731.1
    XP_016877732.1
    XP_016877733.1
    XP_016877734.1
    XP_016877735.1
    XP_016877736.1
    XP_016877737.1
    XP_016877738.1
    XP_016877739.1
    XP_016877740.1
    XP_016877741.1
    XP_016877742.1
    XP_016877743.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029619.1 RefSeqGene

      Range
      5001..384975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007156.2NP_001007157.1  NT-3 growth factor receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001007157.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC021677, BC013693, BM675026, DA789502
      Consensus CDS
      CCDS32323.1
      UniProtKB/TrEMBL
      Q96CY4
      Related
      ENSP00000444673.2, ENST00000540489.6
      Conserved Domains (5) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. NM_001012338.2NP_001012338.1  NT-3 growth factor receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001012338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC009711, AC011966, DA789502, S76475
      Consensus CDS
      CCDS32322.1
      UniProtKB/Swiss-Prot
      Q16288
      UniProtKB/TrEMBL
      X5D2R1
      Related
      ENSP00000354207.2, ENST00000360948.6
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538824
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. NM_001243101.1NP_001230030.1  NT-3 growth factor receptor isoform d precursor

      See identical proteins and their annotated locations for NP_001230030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a.
      Source sequence(s)
      AC011966, AK313646, DA789502
      Consensus CDS
      CCDS58399.1
      UniProtKB/TrEMBL
      X5DNW6
      Related
      ENSP00000347397.3, ENST00000355254.6
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:530802
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:524810
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    4. NM_001320134.1NP_001307063.1  NT-3 growth factor receptor isoform e precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC021677, AF058390, AK309695, BM675026, S76476
      UniProtKB/Swiss-Prot
      Q16288
      UniProtKB/TrEMBL
      O95193
      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    5. NM_001320135.1NP_001307064.1  NT-3 growth factor receptor isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK302504, CD370531, HY003065, S76476
      Consensus CDS
      CCDS81916.1
      UniProtKB/Swiss-Prot
      Q16288
      UniProtKB/TrEMBL
      B7Z7U4
      Related
      ENSP00000437773.2, OTTHUMP00000246909, ENST00000542733.6, OTTHUMT00000415277
      Conserved Domains (7) summary
      cd04971
      Location:221298
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:113203
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00410
      Location:120203
      IG_like; Immunoglobulin like
      sd00031
      Location:730
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:562
      LRR_8; Leucine rich repeat
      pfam16920
      Location:65110
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21453
      Location:434614
      PKc_like; Protein Kinases, catalytic domain
    6. NM_002530.3NP_002521.2  NT-3 growth factor receptor isoform b precursor

      See identical proteins and their annotated locations for NP_002521.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC011966, AC021677, DA789502, U05012
      Consensus CDS
      CCDS10340.1
      UniProtKB/Swiss-Prot
      Q16288
      UniProtKB/TrEMBL
      X5D7M5
      Related
      ENSP00000377990.1, OTTHUMP00000192915, ENST00000394480.6, OTTHUMT00000309066
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538810
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      87859749..88256796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022240.1XP_016877729.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      X5D7M5
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538810
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. XM_006720544.3XP_006720607.1  NT-3 growth factor receptor isoform X2

      See identical proteins and their annotated locations for XP_006720607.1

      UniProtKB/TrEMBL
      X5DNW6
      Related
      ENSP00000453959.1, OTTHUMP00000246908, ENST00000557856.5, OTTHUMT00000415275
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:530802
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:524810
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. XM_006720543.3XP_006720606.1  NT-3 growth factor receptor isoform X1

      See identical proteins and their annotated locations for XP_006720606.1

      UniProtKB/TrEMBL
      X5D7M5
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538810
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    4. XM_017022253.1XP_016877742.1  NT-3 growth factor receptor isoform X18

      UniProtKB/Swiss-Prot
      Q16288
      UniProtKB/TrEMBL
      X5D2R1
      Related
      ENSP00000485864.1, OTTHUMP00000278391, ENST00000629765.2, OTTHUMT00000480548
      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538824
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    5. XM_017022254.1XP_016877743.1  NT-3 growth factor receptor isoform X19

      Conserved Domains (8) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538835
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      cd05094
      Location:532843
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    6. XM_017022244.1XP_016877733.1  NT-3 growth factor receptor isoform X5

    7. XM_017022245.1XP_016877734.1  NT-3 growth factor receptor isoform X5

    8. XM_017022246.1XP_016877735.1  NT-3 growth factor receptor isoform X5

    9. XM_017022243.1XP_016877732.1  NT-3 growth factor receptor isoform X5

    10. XM_017022241.1XP_016877730.1  NT-3 growth factor receptor isoform X3

    11. XM_017022252.1XP_016877741.1  NT-3 growth factor receptor isoform X17

    12. XM_017022251.1XP_016877740.1  NT-3 growth factor receptor isoform X16

    13. XM_006720545.3XP_006720608.1  NT-3 growth factor receptor isoform X6

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21453
      Location:532712
      PKc_like; Protein Kinases, catalytic domain
    14. XM_017022242.1XP_016877731.1  NT-3 growth factor receptor isoform X4

      Related
      ENSP00000453511.1, OTTHUMP00000247313, ENST00000558676.5, OTTHUMT00000416153
    15. XM_017022248.1XP_016877737.1  NT-3 growth factor receptor isoform X9

    16. XM_017022247.1XP_016877736.1  NT-3 growth factor receptor isoform X8

    17. XM_011521637.2XP_011519939.1  NT-3 growth factor receptor isoform X7

      See identical proteins and their annotated locations for XP_011519939.1

      UniProtKB/TrEMBL
      Q96CY4
      Related
      ENSP00000318328.3, OTTHUMP00000240515, ENST00000317501.7, OTTHUMT00000403049
      Conserved Domains (5) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    18. XM_017022249.1XP_016877738.1  NT-3 growth factor receptor isoform X10

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    19. XM_006720548.3XP_006720611.1  NT-3 growth factor receptor isoform X11

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    20. XM_006720550.3XP_006720613.1  NT-3 growth factor receptor isoform X13

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    21. XM_006720549.3XP_006720612.1  NT-3 growth factor receptor isoform X12

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    22. XM_011521638.2XP_011519940.1  NT-3 growth factor receptor isoform X15

      Conserved Domains (7) summary
      cd04971
      Location:319396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:3156
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218301
      IG_like; Immunoglobulin like
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    23. XM_017022250.1XP_016877739.1  NT-3 growth factor receptor isoform X14

    RNA

    1. XR_001751292.1 RNA Sequence

    2. XR_001751293.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      88261800..88641816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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