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    P32 P32 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37006, updated on 16-Jun-2026
    Official Symbol
    P32provided by FlyBase
    Official Full Name
    P32provided by FlyBase
    Primary source
    FLYBASE:FBgn0034259
    Locus tag
    Dmel_CG6459
    See related
    AllianceGenome:FB:FBgn0034259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 6459; CG6459; Dmel\CG6459; dp32; p32; TAP; TAP/p32
    Summary
    Enables histone binding activity. Involved in nucleosome assembly and sperm DNA decondensation. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial tube; gut section; head; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Jul 2025]
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See P32 in Genome Data Viewer
    Location:
    54D4-54D4; 2-83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17671309..17672640, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13558814..13560145, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Induced by Infection Neighboring gene Semaphorin 1b Neighboring gene Hermansky-Pudlak Syndrome 4 Neighboring gene uncharacterized protein

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria. Chen H, et al. Genes (Basel), 2020 Jul 25. PMID 32722516, Free PMC Article
    2. Genetic analysis in Drosophila reveals a role for the mitochondrial protein p32 in synaptic transmission. Lutas A, et al. G3 (Bethesda), 2012 Jan. PMID 22384382, Free PMC Article
    3. The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors. Beckmann JF, et al. Elife, 2019 Nov 27. PMID 31774393, Free PMC Article
    4. Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models. Tio M, et al. J Biomed Sci, 2024 Feb 23. PMID 38395904, Free PMC Article
    5. EGCG ameliorates neuronal and behavioral defects by remodeling gut microbiota and TotM expression in Drosophila models of Parkinson's disease. Xu Y, et al. FASEB J, 2020 Apr. PMID 32157731

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models.
      Title: Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Preferred Names
    P32
    Names
    CG6459-PA
    P32-PA
    protamine chaperone

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17671309..17672640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137399.4 → NP_611243.1  P32

      See identical proteins and their annotated locations for NP_611243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAX4, Q7JXC4
      Related
      FBpp0086051
      Conserved Domains (1) summary
      pfam02330
      Location:68 → 253
      MAM33; Mitochondrial glycoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXC4 Q7JXC4

    Gene LinkOut

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