ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ERBB2provided by HGNC
Official Full Name: erb-b2 receptor tyrosine kinase 2provided by HGNC
Primary source: HGNC:HGNC:3430
See related: Ensembl:ENSG00000141736 MIM:164870; AllianceGenome:HGNC:3430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)
Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (39688094..39728658)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (40551660..40592218)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37844347..37884911)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human epidermal growth factor receptor-2 expression and subsequent dynamic changes in patients with ovarian cancer.
Title: Human epidermal growth factor receptor-2 expression and subsequent dynamic changes in patients with ovarian cancer.
Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting.
Title: Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting.
EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.
Title: EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.
Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2.
Title: Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2.
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma.
Title: Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma.
Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.
Title: Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.
Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy.
Title: Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy.
HER2 Affects the Biological Behaviours of Bladder Cancer Cells and is Closely Associated with the Progression and Prognosis of Bladder Cancer.
Title: HER2 Affects the Biological Behaviours of Bladder Cancer Cells and is Closely Associated with the Progression and Prognosis of Bladder Cancer.
ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
Title: ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
HER2-positive is an independent indicator for predicting pathological complete response to neoadjuvant therapy and Ki67-changed after neoadjuvant chemotherapy predicts favorable prognosis in Chinese women with locally advanced breast cancer.
Title: HER2-positive is an independent indicator for predicting pathological complete response to neoadjuvant therapy and Ki67-changed after neoadjuvant chemotherapy predicts favorable prognosis in Chinese women with locally advanced breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (3035)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cetuximab response MedGen: CN077967 GeneReviews: Not available	Compare labs
Glioma susceptibility 1 MedGen: C2750850 OMIM: 137800 GeneReviews: Not available	Compare labs
Lung cancer MedGen: C0242379 OMIM: 211980 GeneReviews: Not available	Compare labs
Neoplasm of ovary MedGen: C0919267 OMIM: 167000 GeneReviews: Not available	Compare labs
Panitumumab response MedGen: CN077999 GeneReviews: Not available	Compare labs
Pertuzumab response MedGen: CN233145 GeneReviews: Not available	Compare labs
Stomach cancer MedGen: C0024623 OMIM: 613659 GeneReviews: Not available	Compare labs
Trastuzumab response MedGen: CN078025 GeneReviews: Not available	Compare labs
Visceral neuropathy, familial, 2, autosomal recessive MedGen: C5561950 OMIM: 619465 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:180968 (e-PCR)
- UniSTS:155147

GDB:181407 (e-PCR)
- UniSTS:155240

D15S1477 (e-PCR)
- UniSTS:474482

SHGC-67307 (e-PCR)
- UniSTS:89991

D11S3114 (e-PCR)
- UniSTS:152207

RH75810 (e-PCR)
- UniSTS:86180

RH69066 (e-PCR)
- UniSTS:71382

ERBB2_331 (e-PCR)
- UniSTS:277215

GDB:285022 (e-PCR)
- UniSTS:156385

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase I core binding	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of angiogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of microtubule-based process	IDA Inferred from Direct Assay more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of ERBB3:ERBB2 complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	TAS Traceable Author Statement more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
part_of semaphorin receptor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-2

Names: c-erb B2/neu protein; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; proto-oncogene Neu; proto-oncogene c-ErbB-2; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

NP_001005862.1

EC 2.7.10.1

NP_001276865.1

EC 2.7.10.1

NP_001276866.1

EC 2.7.10.1

NP_001276867.1

EC 2.7.10.1

NP_001369711.1

EC 2.7.10.1

NP_001369712.1

EC 2.7.10.1

NP_001369713.1

EC 2.7.10.1

NP_001369714.1

EC 2.7.10.1

NP_001369715.1

EC 2.7.10.1

NP_001369716.1

EC 2.7.10.1

NP_001369717.1

EC 2.7.10.1

NP_001369718.1

EC 2.7.10.1

NP_001369719.1

EC 2.7.10.1

NP_001369720.1

EC 2.7.10.1

NP_001369721.1

EC 2.7.10.1

NP_001369722.1

EC 2.7.10.1

NP_001369723.1

EC 2.7.10.1

NP_001369724.1

EC 2.7.10.1

NP_001369725.1

EC 2.7.10.1

NP_001369726.1

EC 2.7.10.1

NP_001369727.1

EC 2.7.10.1

NP_001369728.1

EC 2.7.10.1

NP_001369729.1

EC 2.7.10.1

NP_001369730.1

EC 2.7.10.1

NP_001369731.1

EC 2.7.10.1

NP_001369732.1

EC 2.7.10.1

NP_001369733.1

EC 2.7.10.1

NP_001369734.1

EC 2.7.10.1

NP_001369735.1

EC 2.7.10.1

NP_004439.2

EC 2.7.10.1

XP_047291546.1

EC 2.7.10.1

XP_054171396.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007503.1 RefSeqGene

Range

4945..45523

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

mRNA and Protein(s)

NM_001005862.3 → NP_001005862.1 receptor tyrosine-protein kinase erbB-2 isoform b

See identical proteins and their annotated locations for NP_001005862.1

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS45667.1

UniProtKB/Swiss-Prot

P04626

Related

ENSP00000462438.1, ENST00000584601.5

Conserved Domains (5) summary

cd12094
Location:611 → 654

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:682 → 960

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:481 → 613

GF_recep_IV; Growth factor receptor domain IV
NM_001289936.2 → NP_001276865.1 receptor tyrosine-protein kinase erbB-2 isoform c

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS74052.1

UniProtKB/Swiss-Prot

P04626

Related

ENSP00000446466.1, ENST00000541774.5

Conserved Domains (8) summary

cd12094
Location:626 → 669

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:542 → 588

FU; Furin-like repeats

cd00064
Location:220 → 265

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:697 → 975

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:174 → 323

Furin-like; Furin-like cysteine rich region

pfam01030
Location:37 → 158

Recep_L_domain; Receptor L domain

pfam07714
Location:705 → 961

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:496 → 628

GF_recep_IV; Growth factor receptor domain IV
NM_001289937.2 → NP_001276866.1 receptor tyrosine-protein kinase erbB-2 isoform d precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS77016.1

UniProtKB/TrEMBL

J3QLU9

Related

ENSP00000463714.1, ENST00000584450.5

Conserved Domains (8) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:557 → 603

FU; Furin-like repeats

cd00064
Location:235 → 280

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam07714
Location:720 → 976

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV
NM_001289938.2 → NP_001276867.1 receptor tyrosine-protein kinase erbB-2 isoform e

Status: REVIEWED

Source sequence(s)

AC087491

Consensus CDS

CCDS77017.1

UniProtKB/TrEMBL

B4DLA2, F5H1T4

Related

ENSP00000462808.1, ENST00000578199.5

Conserved Domains (5) summary

smart00261
Location:527 → 573

FU; Furin-like repeats

cd00064
Location:205 → 250

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:481 → 603

GF_recep_IV; Growth factor receptor domain IV
NM_001382782.1 → NP_001369711.1 receptor tyrosine-protein kinase erbB-2 isoform b

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS45667.1

Conserved Domains (5) summary

cd12094
Location:611 → 654

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:682 → 960

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:481 → 613

GF_recep_IV; Growth factor receptor domain IV
NM_001382783.1 → NP_001369712.1 receptor tyrosine-protein kinase erbB-2 isoform b

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS45667.1

Conserved Domains (5) summary

cd12094
Location:611 → 654

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:682 → 960

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:481 → 613

GF_recep_IV; Growth factor receptor domain IV
NM_001382784.1 → NP_001369713.1 receptor tyrosine-protein kinase erbB-2 isoform f precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:680 → 723

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:751 → 1029

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:550 → 682

GF_recep_IV; Growth factor receptor domain IV
NM_001382785.1 → NP_001369714.1 receptor tyrosine-protein kinase erbB-2 isoform g precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:675 → 718

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:746 → 1024

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 677

GF_recep_IV; Growth factor receptor domain IV
NM_001382786.1 → NP_001369715.1 receptor tyrosine-protein kinase erbB-2 isoform h precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:680 → 723

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1090 → 1219

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:550 → 682

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:751 → 1017

PKc_like; Protein Kinases, catalytic domain
NM_001382787.1 → NP_001369716.1 receptor tyrosine-protein kinase erbB-2 isoform i precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:666 → 709

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:737 → 1015

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:214 → 363

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 198

Recep_L_domain; Receptor L domain

pfam14843
Location:536 → 668

GF_recep_IV; Growth factor receptor domain IV
NM_001382788.1 → NP_001369717.1 receptor tyrosine-protein kinase erbB-2 isoform j precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:651 → 694

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:722 → 1000

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:521 → 653

GF_recep_IV; Growth factor receptor domain IV
NM_001382789.1 → NP_001369718.1 receptor tyrosine-protein kinase erbB-2 isoform k precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:648 → 691

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:719 → 997

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:518 → 650

GF_recep_IV; Growth factor receptor domain IV
NM_001382790.1 → NP_001369719.1 receptor tyrosine-protein kinase erbB-2 isoform l precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:640 → 683

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:711 → 989

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 642

GF_recep_IV; Growth factor receptor domain IV
NM_001382791.1 → NP_001369720.1 receptor tyrosine-protein kinase erbB-2 isoform m precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:638 → 681

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:709 → 987

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:186 → 335

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 170

Recep_L_domain; Receptor L domain

pfam14843
Location:508 → 640

GF_recep_IV; Growth factor receptor domain IV
NM_001382792.1 → NP_001369721.1 receptor tyrosine-protein kinase erbB-2 isoform n precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1051 → 1180

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 978

PKc_like; Protein Kinases, catalytic domain
NM_001382793.1 → NP_001369722.1 receptor tyrosine-protein kinase erbB-2 isoform o precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1049 → 1178

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 976

PKc_like; Protein Kinases, catalytic domain
NM_001382794.1 → NP_001369723.1 receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:698 → 976

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV
NM_001382795.1 → NP_001369724.1 receptor tyrosine-protein kinase erbB-2 isoform q precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (4) summary

cd05109
Location:696 → 974

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 633

GF_recep_IV; Growth factor receptor domain IV
NM_001382796.1 → NP_001369725.1 receptor tyrosine-protein kinase erbB-2 isoform r precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV
NM_001382797.1 → NP_001369726.1 receptor tyrosine-protein kinase erbB-2 isoform s precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1030 → 1159

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 957

PKc_like; Protein Kinases, catalytic domain
NM_001382798.1 → NP_001369727.1 receptor tyrosine-protein kinase erbB-2 isoform t precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1011 → 1140

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 938

PKc_like; Protein Kinases, catalytic domain
NM_001382799.1 → NP_001369728.1 receptor tyrosine-protein kinase erbB-2 isoform u precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:581 → 624

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:652 → 930

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:148 → 278

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 147

Recep_L_domain; Receptor L domain

pfam14843
Location:451 → 583

GF_recep_IV; Growth factor receptor domain IV
NM_001382800.1 → NP_001369729.1 receptor tyrosine-protein kinase erbB-2 isoform v precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:1001 → 1130

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 928

PKc_like; Protein Kinases, catalytic domain
NM_001382801.1 → NP_001369730.1 receptor tyrosine-protein kinase erbB-2 isoform w precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

COG3170
Location:995 → 1124

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 633

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:696 → 922

PKc_like; Protein Kinases, catalytic domain
NM_001382802.1 → NP_001369731.1 receptor tyrosine-protein kinase erbB-2 isoform x precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:555 → 598

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:626 → 904

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:201 → 252

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:425 → 557

GF_recep_IV; Growth factor receptor domain IV
NM_001382803.1 → NP_001369732.1 receptor tyrosine-protein kinase erbB-2 isoform y precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (5) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 976

PKc_like; Protein Kinases, catalytic domain
NM_001382804.1 → NP_001369733.1 receptor tyrosine-protein kinase erbB-2 isoform z precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS92296.1

UniProtKB/TrEMBL

B4DTR1

Related

ENSP00000404047.2, ENST00000445658.6

Conserved Domains (5) summary

cd12094
Location:365 → 408

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:436 → 714

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:25 → 62

Furin-like; Furin-like cysteine rich region

pfam01030
Location:90 → 206

Recep_L_domain; Receptor L domain

pfam14843
Location:235 → 367

GF_recep_IV; Growth factor receptor domain IV
NM_001382805.1 → NP_001369734.1 receptor tyrosine-protein kinase erbB-2 isoform aa precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (6) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

COG3170
Location:746 → 875

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

cl21453
Location:712 → 736

PKc_like; Protein Kinases, catalytic domain
NM_001382806.1 → NP_001369735.1 receptor tyrosine-protein kinase erbB-2 isoform bb precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Conserved Domains (4) summary

COG3170
Location:717 → 846

FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

cl21453
Location:406 → 644

PKc_like; Protein Kinases, catalytic domain
NM_004448.4 → NP_004439.2 receptor tyrosine-protein kinase erbB-2 isoform a precursor

See identical proteins and their annotated locations for NP_004439.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC079199, AC087491, BC167147

Consensus CDS

CCDS32642.1

UniProtKB/Swiss-Prot

B2RZG3, B4DHN3, P04626, Q14256, Q6LDV1, Q9UMK4, X5D2V5

UniProtKB/TrEMBL

X5DNK3

Related

ENSP00000269571.4, ENST00000269571.10

Conserved Domains (8) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:557 → 603

FU; Furin-like repeats

cd00064
Location:235 → 280

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam07714
Location:720 → 976

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV