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    Sipa1 signal-induced proliferation associated gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 20469, updated on 5-Nov-2017
    Official Symbol
    Sipa1provided by MGI
    Official Full Name
    signal-induced proliferation associated gene 1provided by MGI
    Primary source
    MGI:MGI:107576
    See related
    Ensembl:ENSMUSG00000056917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spa1
    Orthologs
    Location:
    19 A; 19 4.34 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (5651185..5663839, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5651185..5663707, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian) Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene mitogen-activated protein kinase kinase kinase 11

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • MAPK Cascade, organism-specific biosystem (from WikiPathways)
      MAPK Cascade, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signalling, organism-specific biosystem (from REACTOME)
      Rap1 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4074

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    signal-induced proliferation-associated protein 1
    Names
    GTPase-activating protein Spa-1
    sipa-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164480.1NP_001157952.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC134563, AK149669, BB843238
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96
      Related
      ENSMUSP00000128208.1, ENSMUST00000164304.7
      Conserved Domains (3) summary
      pfam00595
      Location:683755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347528
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9701026
      DUF904; Protein of unknown function (DUF904)
    2. NM_001164481.1NP_001157953.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4
      Related
      ENSMUSP00000073618.5, ENSMUST00000071857.11
      Conserved Domains (3) summary
      pfam00595
      Location:683755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347528
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9701026
      DUF904; Protein of unknown function (DUF904)
    3. NM_001164482.1NP_001157954.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4
      Conserved Domains (3) summary
      pfam00595
      Location:683755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347528
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9701026
      DUF904; Protein of unknown function (DUF904)
    4. NM_001164568.1NP_001158040.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001158040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC134563, AK028151
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3V403
      Related
      ENSMUSP00000132345.1, ENSMUST00000169854.1
      Conserved Domains (3) summary
      pfam00595
      Location:683755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347528
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9701026
      DUF904; Protein of unknown function (DUF904)
    5. NM_011379.4NP_035509.4  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_035509.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4
      Related
      ENSMUSP00000079637.5, ENSMUST00000080824.11
      Conserved Domains (3) summary
      pfam00595
      Location:683755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347528
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9701026
      DUF904; Protein of unknown function (DUF904)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      5651185..5663839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318100.1XP_017173589.1  signal-induced proliferation-associated protein 1 isoform X1

    2. XM_017318103.1XP_017173592.1  signal-induced proliferation-associated protein 1 isoform X1

    3. XM_017318098.1XP_017173587.1  signal-induced proliferation-associated protein 1 isoform X1

    4. XM_017318099.1XP_017173588.1  signal-induced proliferation-associated protein 1 isoform X1

    5. XM_017318104.1XP_017173593.1  signal-induced proliferation-associated protein 1 isoform X1

    6. XM_017318102.1XP_017173591.1  signal-induced proliferation-associated protein 1 isoform X1

    7. XM_017318101.1XP_017173590.1  signal-induced proliferation-associated protein 1 isoform X1

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