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    MYO1G myosin IG [ Homo sapiens (human) ]

    Gene ID: 64005, updated on 4-Jun-2017
    Official Symbol
    MYO1Gprovided by HGNC
    Official Full Name
    myosin IGprovided by HGNC
    Primary source
    HGNC:HGNC:13880
    See related
    Ensembl:ENSG00000136286 MIM:600642; Vega:OTTHUMG00000155821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA2; MHAG; HLA-HA2
    Summary
    MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
    Orthologs
    Location:
    7p13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (44962661..44979105, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45002260..45018704, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375262 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1 Neighboring gene uncharacterized LOC102723334 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene CCM2 scaffolding protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of myosin IG (MYO1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC142104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell mediated immunity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell gliding IEA
    Inferred from Electronic Annotation
    more info
     
    cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    leading edge membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    unconventional myosin-Ig
    Names
    minor histocompatibility antigen HA-2
    myosin-Ig

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033054.2NP_149043.2  unconventional myosin-Ig

      See identical proteins and their annotated locations for NP_149043.2

      Status: VALIDATED

      Source sequence(s)
      AA651942, AC004847, BC117241, DB131347
      Consensus CDS
      CCDS34629.1
      UniProtKB/Swiss-Prot
      B0I1T2
      Related
      ENSP00000258787.7, OTTHUMP00000208732, ENST00000258787.11, OTTHUMT00000341832
      Conserved Domains (3) summary
      smart00242
      Location:4706
      MYSc; Myosin. Large ATPases
      cd01378
      Location:23694
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:815980
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      44962661..44979105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012504.1XP_016867993.1  unconventional myosin-Ig isoform X2

    2. XM_017012503.1XP_016867992.1  unconventional myosin-Ig isoform X1

    RNA

    1. XR_926943.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      45006172..45022616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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