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    HIF3A hypoxia inducible factor 3 subunit alpha [ Manis javanica (Malayan pangolin) ]

    Gene ID: 108398976, updated on 14-Mar-2024

    Summary

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    Gene symbol
    HIF3A
    Gene description
    hypoxia inducible factor 3 subunit alpha
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Manis javanica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
    Orthologs
    human mouse all
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    Genomic context

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    See HIF3A in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023450481.1 (856726..883557, complement)
    100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016534420.1 (19801..47503)

    NW_023450481.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118969933 Neighboring gene paraneoplastic antigen-like protein 8A Neighboring gene protein phosphatase 5 catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hypoxia-inducible factor 3-alpha
    Names
    hypoxia inducible factor 3 alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference YNU_ManJav_2.0 Primary Assembly

    Genomic

    1. NW_023450481.1 Reference YNU_ManJav_2.0 Primary Assembly

      Range
      856726..883557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037004995.1 → XP_036860890.1  hypoxia-inducible factor 3-alpha isoform X2

      Conserved Domains (5) summary
      PHA03247
      Location:374 → 769
      PHA03247; large tegument protein UL36; Provisional
      cd00130
      Location:95 → 170
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:251 → 338
      PAS_3; PAS fold
      cd19729
      Location:12 → 74
      bHLH-PAS_HIF3a_PASD7; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 3-alpha (HIF3a) and similar proteins
      pfam11413
      Location:480 → 509
      HIF-1; Hypoxia-inducible factor-1

    2. XM_037004997.1 → XP_036860892.1  hypoxia-inducible factor 3-alpha isoform X4

      Conserved Domains (4) summary
      PHA03247
      Location:277 → 672
      PHA03247; large tegument protein UL36; Provisional
      cd00130
      Location:1 → 73
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:154 → 241
      PAS_3; PAS fold
      pfam11413
      Location:383 → 412
      HIF-1; Hypoxia-inducible factor-1

    3. XM_037004996.1 → XP_036860891.1  hypoxia-inducible factor 3-alpha isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:318 → 713
      PHA03247; large tegument protein UL36; Provisional
      cd00130
      Location:39 → 114
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:195 → 282
      PAS_3; PAS fold
      pfam11413
      Location:424 → 453
      HIF-1; Hypoxia-inducible factor-1
      cl00081
      Location:1 → 18
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    4. XM_037004994.1 → XP_036860889.1  hypoxia-inducible factor 3-alpha isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:393 → 788
      PHA03247; large tegument protein UL36; Provisional
      cd00130
      Location:114 → 189
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:270 → 357
      PAS_3; PAS fold
      cd19729
      Location:31 → 93
      bHLH-PAS_HIF3a_PASD7; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 3-alpha (HIF3a) and similar proteins
      pfam11413
      Location:499 → 528
      HIF-1; Hypoxia-inducible factor-1

    5. XM_037004993.1 → XP_036860888.1  hypoxia-inducible factor 3-alpha isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:393 → 788
      PHA03247; large tegument protein UL36; Provisional
      cd00130
      Location:114 → 189
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:270 → 357
      PAS_3; PAS fold
      cd19729
      Location:31 → 93
      bHLH-PAS_HIF3a_PASD7; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 3-alpha (HIF3a) and similar proteins
      pfam11413
      Location:499 → 528
      HIF-1; Hypoxia-inducible factor-1

    6. XM_017663430.2 → XP_017518919.1  hypoxia-inducible factor 3-alpha isoform X6

    7. XM_017663428.2 → XP_017518917.1  hypoxia-inducible factor 3-alpha isoform X5

    Nucleotide Protein
    Heading Accession and Version

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