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    bamA outer membrane protein assembly factor BamA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944870, updated on 4-Apr-2024

    Summary

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    Gene symbol
    bamA
    Gene description
    outer membrane protein assembly factor BamA
    Primary source
    ASAP:ABE-0000605
    Locus tag
    b0177
    See related
    ECOCYC:G6093
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ecfK; ECK0176; yaeT; yzzN; yzzY
    Summary
    bamA is an essential gene. [More information is available at EcoGene: EG12676]. Copurification experiments and sequence analysis identified YaeT, YfiO, NlpB, and SmpA as forming a large protein complex with YfgL involved in outer membrane protein (OMP) biogenesis. [More information is available at EcoCyc: G6093].
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    Genomic context

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    Sequence:
    NC_000913.3 (197928..200360)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene CDP-diglyceride synthetase Neighboring gene intramembrane zinc metalloprotease RseP Neighboring gene periplasmic chaperone Skp Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BamA forms a translocation channel for polypeptide export across the bacterial outer membrane. Doyle MT, et al. Mol Cell, 2021 May 6. PMID 33705710, Free PMC Article
    2. Characterization of BamA reconstituted into a solid-supported lipid bilayer as a platform for measuring dynamics during substrate protein assembly into the membrane. Ding Y, et al. Biochim Biophys Acta Biomembr, 2020 Sep 1. PMID 32380170
    3. BamA is required for autotransporter secretion. Ryoo D, et al. Biochim Biophys Acta Gen Subj, 2020 Jul. PMID 32114025, Free PMC Article
    4. Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel. Doyle MT, et al. Nat Commun, 2019 Jul 26. PMID 31350400, Free PMC Article
    5. The Escherichia coli β-Barrel Assembly Machinery Is Sensitized to Perturbations under High Membrane Fluidity. Storek KM, et al. J Bacteriol, 2019 Jan 1. PMID 30322857, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Escherichia coli Outer Membrane beta-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.
      Title: The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.
    2. The transmembrane supercomplex mediating the biogenesis of OMPs in Gram-negative bacteria assumes a circular conformational change upon activation.
      Title: The transmembrane supercomplex mediating the biogenesis of OMPs in Gram-negative bacteria assumes a circular conformational change upon activation.
    3. Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress.
      Title: Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress.
    4. BamA forms a translocation channel for polypeptide export across the bacterial outer membrane.
      Title: BamA forms a translocation channel for polypeptide export across the bacterial outer membrane.
    5. Characterization of BamA reconstituted into a solid-supported lipid bilayer as a platform for measuring dynamics during substrate protein assembly into the membrane.
      Title: Characterization of BamA reconstituted into a solid-supported lipid bilayer as a platform for measuring dynamics during substrate protein assembly into the membrane.
    6. Structural insight into the formation of lipoprotein-beta-barrel complexes.
      Title: Structural insight into the formation of lipoprotein-β-barrel complexes.
    7. BamA is required for autotransporter secretion.
      Title: BamA is required for autotransporter secretion.
    8. Data indicate structural variations in the central domain, outer membrane protein BamA (BamA), as well as in the lipoprotein outer membrane protein assembly factor BamC (BamC).
      Title: Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy.
    9. The results support a model in which the interior wall of BamA acts as a chaperone to catalyze b-barrel assembly via binding with its substrate, LptD.
      Title: Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA.
    10. The role of BamE is to promote proper coordination of RcsF-bound BamA with BamD to complete outer membrane protein assembly around RcsF.
      Title: Improper Coordination of BamA and BamD Results in Bam Complex Jamming by a Lipoprotein Substrate.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Gram-negative-bacterium-type cell outer membrane assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Gram-negative-bacterium-type cell outer membrane assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein insertion into membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Bam protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Bam protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Bam protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer membrane protein assembly factor BamA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      197928..200360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414719.1 outer membrane protein assembly factor BamA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414719.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AAC7
      Conserved Domains (1) summary
      PRK11067
      Location:1 → 810
      PRK11067; outer membrane protein assembly factor YaeT; Provisional
    Nucleotide Protein
    Heading Accession and Version

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