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    IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 169355, updated on 22-Apr-2017
    Official Symbol
    IDO2provided by HGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:27269
    See related
    Ensembl:ENSG00000188676 MIM:612129; Vega:OTTHUMG00000141271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INDOL1
    Summary
    Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
    Orthologs
    Location:
    8p11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (39934955..40016391)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39792474..39873910)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene polo like kinase 4 pseudogene Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene uncharacterized LOC105379385 Neighboring gene uncharacterized LOC105379386 Neighboring gene chromosome 8 open reading frame 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    indoleamine 2,3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    indoleamine 2,3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan 2,3-dioxygenase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan catabolic process TAS
    Traceable Author Statement
    more info
     
    tryptophan catabolic process to kynurenine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan catabolic process to kynurenine ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    indoleamine 2,3-dioxygenase 2
    Names
    IDO-2
    indoleamine 2,3-dioxygenase-like 1 protein
    indoleamine 2,3-dioxygenase-like protein 1
    indoleamine-pyrrole 2,3 dioxygenase-like 1
    indoleamine-pyrrole 2,3-dioxygenase-like protein 1
    NP_919270.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194294.2NP_919270.2  indoleamine 2,3-dioxygenase 2

      Status: VALIDATED

      Source sequence(s)
      AC087518, AK128691, EF052681
      Consensus CDS
      CCDS6114.2
      UniProtKB/Swiss-Prot
      Q6ZQW0
      Related
      ENSP00000443432.1, ENST00000502986.2
      Conserved Domains (1) summary
      pfam01231
      Location:28414
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      39934955..40016391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      39839074..39920934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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