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    Mc4r melanocortin 4 receptor [ Mus musculus (house mouse) ]

    Gene ID: 17202, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mc4rprovided by MGI
    Official Full Name
    melanocortin 4 receptorprovided by MGI
    Primary source
    MGI:MGI:99457
    See related
    Ensembl:ENSMUSG00000047259 AllianceGenome:MGI:99457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkcp; Mc4-r
    Summary
    This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E1; 18 39.72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66990776..66993558, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66857705..66860487, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41762 Neighboring gene predicted gene, 22219 Neighboring gene predicted gene, 30190 Neighboring gene STARR-seq mESC enhancer starr_44866 Neighboring gene STARR-seq mESC enhancer starr_44867 Neighboring gene STARR-seq mESC enhancer starr_44868 Neighboring gene predicted gene, 19784 Neighboring gene STARR-seq mESC enhancer starr_44869 Neighboring gene predicted gene, 57656

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation. Singh U, et al. Physiol Behav, 2023 Apr 1. PMID 36736416, Free PMC Article
    2. MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity. Wang X, et al. Diabetes, 2022 Nov 1. PMID 35926095
    3. Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue. Morita S, et al. Sci Rep, 2022 Jun 16. PMID 35710868, Free PMC Article
    4. Melanocortin MC(4)R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Oliveira V, et al. Physiol Genomics, 2022 Jun 1. PMID 35476598, Free PMC Article
    5. Stimulation of G(s) signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice. Matsumura S, et al. Am J Physiol Endocrinol Metab, 2022 May 1. PMID 35344393

    See all (278) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.
      Title: Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.
    2. A human obesity-associated MC4R mutation with defective Gq/11alpha signaling leads to hyperphagia in mice.
      Title: A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice.
    3. Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.
      Title: Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.
    4. Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
      Title: Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
    5. Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.
      Title: Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.
    6. Glutamatergic melanocortin-4 receptor neurons regulate body weight.
      Title: Glutamatergic melanocortin-4 receptor neurons regulate body weight.
    7. Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.
      Title: Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.
    8. Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.
      Title: Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.
    9. Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways.
      Title: Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways.
    10. MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity.
      Title: MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity.
    Submit: New GeneRIF Correction See all GeneRIFs (119)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melanocortin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables melanocortin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melanocyte-stimulating hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables melanocyte-stimulating hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables melanocyte-stimulating hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to melanocyte-stimulating hormone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanocortin receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016977.4 → NP_058673.2  melanocortin receptor 4

      See identical proteins and their annotated locations for NP_058673.2

      Status: REVIEWED

      Source sequence(s)
      AK136793, BB633776, BY646801
      Consensus CDS
      CCDS29316.1
      UniProtKB/Swiss-Prot
      P56450, Q49NR4, Q9EQM7
      UniProtKB/TrEMBL
      Q49NR1
      Related
      ENSMUSP00000054776.3, ENSMUST00000057942.4
      Conserved Domains (1) summary
      cd15353
      Location:45 → 313
      7tmA_MC4R; melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      66990776..66993558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56450.3 GenPept UniProtKB/Swiss-Prot:P56450

    Gene LinkOut

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