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    Clca4 chloride channel accessory 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362053, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Clca4provided by RGD
    Official Full Name
    chloride channel accessory 4provided by RGD
    Primary source
    RGD:1303234
    See related
    Ensembl:ENSRNOG00000029889 AllianceGenome:RGD:1303234
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prp3; Clca6
    Summary
    Predicted to enable intracellular calcium activated chloride channel activity. Predicted to be involved in chloride transport and proteolysis. Predicted to be integral component of plasma membrane. Orthologous to human CLCA4 (chloride channel accessory 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 18.3), Kidney (RPKM 7.3) and 4 other tissues See more
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    Genomic context

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    Location:
    2q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (236543975..236565096, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (233883625..233904993, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (250842939..250864060, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478851 Neighboring gene uncharacterized LOC102549543 Neighboring gene chloride channel calcium activated 4-like Neighboring gene chloride channel accessory 1 Neighboring gene chloride channel accessory 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a calcium-activated chloride channel in rat uterus. Song J, et al. Biol Reprod, 2009 Apr. PMID 19144963
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated chloride channel regulator 4
    Names
    chloride channel calcium activated 4
    chloride channel calcium activated 6 protein
    chloride channel regulator 4
    chloride channel, calcium activated, family member 4
    parturition-related protein PRP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201419.1 → NP_958822.1  calcium-activated chloride channel regulator 4 precursor

      See identical proteins and their annotated locations for NP_958822.1

      Status: PROVISIONAL

      Source sequence(s)
      AY333961
      UniProtKB/TrEMBL
      A0A8I5ZJ95, Q6VPP3
      Related
      ENSRNOP00000076720.1, ENSRNOT00000103694.1
      Conserved Domains (2) summary
      cd00198
      Location:306 → 460
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:25 → 897
      CLCA; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      236543975..236565096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282230.1 → XP_063138300.1  calcium-activated chloride channel regulator 4 isoform X1

      UniProtKB/TrEMBL
      Q6VPP3

    2. XM_063282231.1 → XP_063138301.1  calcium-activated chloride channel regulator 4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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