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    Dscam DS cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 13508, updated on 22-Apr-2017
    Official Symbol
    Dscamprovided by MGI
    Official Full Name
    DS cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:1196281
    See related
    Ensembl:ENSMUSG00000050272 Vega:OTTMUSG00000017081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932410A21Rik
    Orthologs
    Location:
    16 C4; 16 57.02 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (96587452..97170735, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (96813686..97392342, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, member 5 Neighboring gene predicted gene, 32358 Neighboring gene integrin beta 2-like Neighboring gene Purkinje cell protein 4 Neighboring gene predicted gene, 32509 Neighboring gene predicted gene, 32432 Neighboring gene beta-site APP-cleaving enzyme 2 Neighboring gene MX dynamin-like GTPase 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite self-avoidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension involved in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    Down syndrome cell adhesion molecule homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031174.4NP_112451.1  Down syndrome cell adhesion molecule homolog precursor

      See identical proteins and their annotated locations for NP_112451.1

      Status: VALIDATED

      Source sequence(s)
      AC154387, AC154814, AF315558
      Consensus CDS
      CCDS37415.1
      UniProtKB/Swiss-Prot
      Q9ERC8
      Related
      ENSMUSP00000056040.7, OTTMUSP00000018561, ENSMUST00000056102.7, OTTMUST00000041363
      Conserved Domains (8) summary
      cd00096
      Location:424493
      Ig; Immunoglobulin domain
      cd05734
      Location:707784
      Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
      smart00408
      Location:239300
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:44113
      IG; Immunoglobulin
      smart00410
      Location:236310
      IG_like; Immunoglobulin like
      cd00063
      Location:13801470
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:690784
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:802889
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      96587452..97170735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522886.2XP_006522949.1  Down syndrome cell adhesion molecule homolog isoform X1

      Conserved Domains (8) summary
      cd00096
      Location:424493
      Ig; Immunoglobulin domain
      cd05734
      Location:707784
      Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
      smart00408
      Location:239300
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:44113
      IG; Immunoglobulin
      smart00410
      Location:236310
      IG_like; Immunoglobulin like
      cd00063
      Location:13801470
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:690784
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:802889
      Ig; Immunoglobulin domain
    2. XM_006522887.2XP_006522950.1  Down syndrome cell adhesion molecule homolog isoform X3

      Conserved Domains (3) summary
      smart00408
      Location:343407
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:343417
      IG_like; Immunoglobulin like
      cd00063
      Location:421511
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_011246093.1XP_011244395.1  Down syndrome cell adhesion molecule homolog isoform X2

      Conserved Domains (8) summary
      cd00096
      Location:424493
      Ig; Immunoglobulin domain
      cd05734
      Location:707784
      Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
      smart00408
      Location:239300
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:44113
      IG; Immunoglobulin
      smart00410
      Location:236310
      IG_like; Immunoglobulin like
      cd00063
      Location:885978
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:690784
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:802889
      Ig; Immunoglobulin domain

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_187016.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      2079..116246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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