DMC1 DNA repair (Rad51) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: DMC1
Gene description: DNA repair (Rad51) family protein
Primary source: Araport:AT3G22880
Locus tag: AT3G22880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS HOMOLOG OF LILY MESSAGES INDUCED AT MEIOSIS 15; ARABIDOPSIS THALIANA DISRUPTION OF MEIOTIC CONTROL 1; ARLIM15; ATDMC1; DISRUPTION OF MEIOTIC CONTROL 1
Summary: Expression of the AtDMC1 is restricted to pollen mother cells in anthers and to megaspore mother cells in ovules. Similar to meiosis-specific yeast DMC gene.
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Genomic context

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See DMC1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 15

Sequence:: Chromosome: 3; NC_003074.8 (8097678..8100932, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Title: RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Both AtRAD51 and AtDMC1 possess ATP hydrolyzing activity, filament formation activity and homologous pairing activity in vitro.
Title: Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1.
KLU is required for normal DMC1 expression pattern in ovules undergoing megasporogenesis.
Title: Comparative expression profiling reveals gene functions in female meiosis and gametophyte development in Arabidopsis.
The DMC1 siRNA interfered with meiotic progression and, consequently, the flowers were at least partially sterile.
Title: Graft-transmissible movement of inverted-repeat-induced siRNA signals into flowers.
Our data demonstrate that RAD51 plays a supporting role for DMC1 in meiotic recombination in the flowering plant, Arabidopsis.
Title: Meiotic recombination in Arabidopsis is catalysed by DMC1, with RAD51 playing a supporting role.
We propose that MCM8 is involved with RAD51 in a backup pathway that repairs meiotic DSB without giving CO when the major pathway, which relies on DMC1, fails.
Title: MCM8 is required for a pathway of meiotic double-strand break repair independent of DMC1 in Arabidopsis thaliana.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Title: The recombinases DMC1 and RAD51 are functionally and spatially separated during meiosis in Arabidopsis.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1, while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51 .
Title: Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
AtRAD51 may be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
Title: Together yes, but not coupled: new insights into the roles of RAD51 and DMC1 in plant meiotic recombination.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Title: BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS16049 (e-PCR)
- UniSTS:258844

Homology

Orthologs from OrthoDB

NM_001338602.1

Supported by ESTs:

NM_113188.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chiasma assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DNA repair (Rad51) family protein

NP_188928.2

DISRUPTION OF MEIOTIC CONTROL 1 (DMC1); FUNCTIONS IN: in 6 functions; INVOLVED IN: DNA repair, meiosis, chiasma assembly, reciprocal meiotic recombination, DNA metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA repair Rad51/transcription factor NusA, alpha-helical (InterPro:IPR010995), ATPase, AAA+ type, core (InterPro:IPR003593), Meiotic recombinase Dmc1 (InterPro:IPR011940), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination/repair protein RecA, monomer-monomer interface (InterPro:IPR020587), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51 (TAIR:AT5G20850.1); Has 11998 Blast hits to 11924 proteins in 3797 species: Archae - 689; Bacteria - 8026; Metazoa - 742; Fungi - 447; Plants - 503; Viruses - 22; Other Eukaryotes - 1569 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

8097678..8100932 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113188.3 → NP_188928.2 DNA repair (Rad51) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188928.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P93001, Q39009, Q4V3A9, Q9LIL0

UniProtKB/TrEMBL

A0A178VEK4, A0A5S9XF07, A0A654F9S0

Conserved Domains (1) summary

PLN03187
Location:1 → 344

PLN03187; meiotic recombination protein DMC1 homolog; Provisional
NM_001338602.1 → NP_001327749.1 DNA repair (Rad51) family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LT97, A0A5S9XF07, A0A654F9S0