NGF nerve growth factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: NGFprovided by HGNC
Official Full Name: nerve growth factorprovided by HGNC
Primary source: HGNC:HGNC:7808
See related: Ensembl:ENSG00000134259 MIM:162030; AllianceGenome:HGNC:7808
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NGFB; HSAN5; Beta-NGF
Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in ovary (RPKM 1.3), heart (RPKM 0.5) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (115285917..115338249, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (115297082..115349408, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (115828538..115880870, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nerve Bundle Density and Expression of NGF and IL-1beta Are Intra-Individually Heterogenous in Subtypes of Endometriosis.
Title: Nerve Bundle Density and Expression of NGF and IL-1β Are Intra-Individually Heterogenous in Subtypes of Endometriosis.
Role of nerve growth factor on cognitive impairment in patients with Alzheimer's disease carrying apolipoprotein E epsilon4.
Title: Role of nerve growth factor on cognitive impairment in patients with Alzheimer's disease carrying apolipoprotein E ε4.
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
Title: HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.
NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis.
Title: NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis.
Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor.
Title: Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor.
Level of Secretion and the Role of the Nerve Growth Factor in Patients with Keratoconus before and after Collagen Fibre Cross-Linking Surgery.
Title: Level of Secretion and the Role of the Nerve Growth Factor in Patients with Keratoconus before and after Collagen Fibre Cross-Linking Surgery.
Multidisciplinary team collaboration impact on NGF, BDNF, serum IGF-1, and life quality in patients with hemiplegia after stroke.
Title: Multidisciplinary team collaboration impact on NGF, BDNF, serum IGF-1, and life quality in patients with hemiplegia after stroke.
A Vicious NGF-p75[NTR] Positive Feedback Loop Exacerbates the Toxic Effects of Oxidative Damage in the Human Retinal Epithelial Cell Line ARPE-19.
Title: A Vicious NGF-p75(NTR) Positive Feedback Loop Exacerbates the Toxic Effects of Oxidative Damage in the Human Retinal Epithelial Cell Line ARPE-19.
Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment.
Title: Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment.
Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis.
Title: Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis.

Submit: New GeneRIF Correction See all GeneRIFs (322)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital sensory neuropathy with selective loss of small myelinated fibers MedGen: C0020075 OMIM: 608654 GeneReviews: Congenital Insensitivity to Pain Overview	Compare labs

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of NGFB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed
	tat	Nerve growth factor synergizes with HIV-1 Tat to induce HIV-1 gene expression in neuronal and glial cell lines	PubMed
	tat	Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter	PubMed
	tat	HIV-1 Tat shows the ability to inhibit the nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells	PubMed
Vpr	vpr	Treatment of cultured dorsal root ganglion sensory neurons with HIV-1 Vpr downregulates expression of TrKA and pGSK3beta/GSK3beta proteins and pre-treatment with NGF inhibits this Vpr-induced downregulation of TrKA and pGSK3beta/GSK3beta	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S2148 (e-PCR)
- UniSTS:151834

D1S3540 (e-PCR)
- UniSTS:7455

D1S2206 (e-PCR)
- UniSTS:151841

D1S2209 (e-PCR)
- UniSTS:151844

D1S2220 (e-PCR)
- UniSTS:151854

NoName (e-PCR)
- UniSTS:486722

NGFB (e-PCR)
- UniSTS:253017

NoName (e-PCR)
- UniSTS:495208

SHGC-75366 (e-PCR)
- UniSTS:32107

GDB:181532 (e-PCR)
- UniSTS:155258

hsbngfac (e-PCR)
- UniSTS:65407

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables death receptor agonist activity	IGI Inferred from Genetic Interaction more info	PubMed
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of axon extension	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peripheral nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of neuron differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of neuron maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-nerve growth factor

Names: nerve growth factor (beta polypeptide); nerve growth factor, beta subunit; pro-nerve growth factor long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007944.1 RefSeqGene

Range

5001..57321

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_260

mRNA and Protein(s)

NM_001437545.1 → NP_001424474.1 beta-nerve growth factor precursor

Status: REVIEWED

Source sequence(s)

AL049825, AL512638

UniProtKB/Swiss-Prot

A1A4E5, P01138, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
NM_002506.3 → NP_002497.2 beta-nerve growth factor precursor

See identical proteins and their annotated locations for NP_002497.2

Status: REVIEWED

Source sequence(s)

AL512638, BC032517, BE045524, CR541855, X52599

Consensus CDS

CCDS882.1

UniProtKB/Swiss-Prot

A1A4E5, P01138, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8

Related

ENSP00000358525.2, ENST00000369512.3

Conserved Domains (1) summary

pfam00243
Location:128 → 237

NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

115285917..115338249 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006710663.4 → XP_006710726.1 beta-nerve growth factor isoform X2

Related

ENSP00000502831.1, ENST00000675637.2

Conserved Domains (1) summary

pfam00243
Location:128 → 237

NGF; Nerve growth factor family
XM_011541518.3 → XP_011539820.1 beta-nerve growth factor isoform X1

UniProtKB/TrEMBL

A0A346FYQ1

Conserved Domains (1) summary

pfam00243
Location:183 → 291

NGF; Nerve growth factor family

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

115297082..115349408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336790.1 → XP_054192765.1 beta-nerve growth factor isoform X2
XM_054336789.1 → XP_054192764.1 beta-nerve growth factor isoform X1

UniProtKB/TrEMBL

A0A346FYQ1