lem-2 LEM protein 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: lem-2
Gene description: LEM protein 2
Primary source: WormBase:WBGene00002275
Locus tag: CELE_W01G7.5
See related: AllianceGenome:WB:WBGene00002275
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables chromatin DNA binding activity and lamin binding activity. Involved in chromosome segregation; mitotic cytokinesis; and response to X-ray. Located in nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to human LEMD3 (LEM domain containing 3) and LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (14063450..14066646)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle.
Title: Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
LEM-2 is localized to the nuclear membrane in every cell of C. elegans embryos. The genes in LEM-2 subdomains tend to be inactive, while those in gaps tend to be active.
Title: Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39G8C.a (e-PCR)
- UniSTS:323649

W01G7.5 (e-PCR)
- UniSTS:307131

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lamin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule organizing center organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane reassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LEM protein 2

NP_496944.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14063450..14066646

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064543.3 → NP_496944.1 LEM protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496944.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTB5

Conserved Domains (2) summary

cd12940
Location:3 → 35

LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

pfam09402
Location:384 → 492

MSC; Man1-Src1p-C-terminal domain