PRG4 proteoglycan 4 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PRG4provided by VGNC
Official Full Name: proteoglycan 4provided by VGNC
Primary source: VGNC:VGNC:33314
See related: Ensembl:ENSBTAG00000011932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MSF; lubricin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (67380946..67398481)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Creb5 establishes the competence for Prg4 expression in articular cartilage.
Title: Creb5 establishes the competence for Prg4 expression in articular cartilage.
YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes.
Title: YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes.
TGF-beta1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin much higher compared with twice-a-week treatment.
Title: Optimization of Methods for Articular Cartilage Surface Tissue Engineering: Cell Density and Transforming Growth Factor Beta Are Critical for Self-Assembly and Lubricin Secretion.
the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.
Title: Effect of disulfide bonding and multimerization on proteoglycan 4's cartilage boundary lubricating ability and adsorption.
The present investigation provides novel insights into the role of the Wnt signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.
Title: Regulation of lubricin/superficial zone protein by Wnt signalling in bovine synoviocytes.
The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.
Title: The distribution of superficial zone protein (SZP)/lubricin/PRG4 and boundary mode frictional properties of the bovine diarthrodial joint.
The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.
Title: Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation by Glycosaminoglycans.
Lubricin expression in explant cartilage was also suppressed under hypoxia
Title: Oxygen tension affects lubricin expression in chondrocytes.
The finding that rhPRG4 can increase the viscosity of low concentration HA solutions suggests that supplementation with rhPRG4 may help mitigate the loss in synovial fluid viscosity experienced with decreased HA concentration in osteoarthritis.
Title: Effects of concentration and structure on proteoglycan 4 rheology and interaction with hyaluronan.
SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta.
Title: Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: proteoglycan 4

Names: MLL septin-like fusion; proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206633.1 → NP_001193562.1 proteoglycan 4 precursor

Status: VALIDATED

Source sequence(s)

AAFC03110221, AAFC03110223, AAFC03113191

UniProtKB/TrEMBL

F1MDS0

Related

ENSBTAP00000015839.5, ENSBTAT00000015839.5

Conserved Domains (4) summary

smart00201
Location:25 → 67

SO; Somatomedin B -like domains

cd00094
Location:934 → 1194

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam02389
Location:443 → 576

Cornifin; Cornifin (SPRR) family

pfam10310
Location:531 → 623

DUF2413; Protein of unknown function (DUF2413)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

Range

67380946..67398481

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024975998.2 → XP_024831766.1 proteoglycan 4 isoform X3

UniProtKB/TrEMBL

G3MYM8

Conserved Domains (3) summary

smart00201
Location:25 → 67

SO; Somatomedin B -like domains

cd00094
Location:1305 → 1565

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cl26464
Location:403 → 1012

Atrophin-1; Atrophin-1 family
XM_024975994.2 → XP_024831762.1 proteoglycan 4 isoform X1

UniProtKB/TrEMBL

A0A3Q1LZ67, G3MYM8

Related

ENSBTAP00000054664.3, ENSBTAT00000064366.3

Conserved Domains (5) summary

smart00201
Location:25 → 67

SO; Somatomedin B -like domains

COG3889
Location:116 → 277

COG3889; Predicted periplasmic protein [Function unknown]

cd00094
Location:1214 → 1474

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cl26386
Location:226 → 391

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

cl26464
Location:312 → 921

Atrophin-1; Atrophin-1 family
XM_024975996.2 → XP_024831764.1 proteoglycan 4 isoform X2

UniProtKB/TrEMBL

A0A3Q1M1S2, G3MYM8

Conserved Domains (5) summary

smart00201
Location:24 → 66

SO; Somatomedin B -like domains

COG3889
Location:75 → 236

COG3889; Predicted periplasmic protein [Function unknown]

cd00094
Location:1173 → 1433

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cl26386
Location:185 → 350

DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

cl26464
Location:271 → 885

Atrophin-1; Atrophin-1 family