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    Pc Polycomb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40358, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Pcprovided by FlyBase
    Official Full Name
    Polycombprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003042
    Locus tag
    Dmel_CG32443
    See related
    AllianceGenome:FB:FBgn0003042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32443; CG7618; Dmel\CG32443; DmPc; dPC; pc; PC; Pc-G; PcG
    Summary
    Enables chromatin binding activity; methylated histone binding activity; and sequence-specific DNA binding activity. Involved in several processes, including neuron remodeling; regionalization; and regulation of gene expression. Located in chromatin; nucleolus; and polytene chromosome band. Part of PRC1 complex. Is expressed in several structures, including central nervous system; embryonic/larval digestive system; extended germ band embryo; gonad; and presumptive embryonic/larval system. Used to study cancer. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5; breast cancer; hepatocellular carcinoma; multiple myeloma; and myeloid leukemia. Orthologous to several human genes including CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    78C6-78C7; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21306138..21318020, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21299238..21311120, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45432 Neighboring gene antisense RNA:CR45952 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45674 Neighboring gene Rab26 Neighboring gene antisense RNA:CR46068

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Order and stochasticity in the folding of individual Drosophila genomes. Ulianov SV, et al. Nat Commun, 2021 Jan 4. PMID 33397980, Free PMC Article
    2. Revisiting the organization of Polycomb-repressed domains: 3D chromatin models from Hi-C compared with super-resolution imaging. Liu L, et al. Nucleic Acids Res, 2020 Nov 18. PMID 33095877, Free PMC Article
    3. Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes. Lehmann L, et al. J Biol Chem, 2012 Oct 19. PMID 22910904, Free PMC Article
    4. Concerted epigenetic signatures inheritance at PcG targets through replication. Lanzuolo C, et al. Cell Cycle, 2012 Apr 1. PMID 22421150, Free PMC Article
    5. Homoeosis in Drosophila. II. a Genetic Analysis of Polycomb. Denell RE. Genetics, 1978 Oct. PMID 17248863, Free PMC Article

    See all (817) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced histone gene copy number disrupts Drosophila Polycomb function.
      Title: Reduced histone gene copy number disrupts Drosophila Polycomb function.
    2. Polycomb repressive complex 1 initiates and maintains tailless repression in Drosophila embryo.
      Title: Polycomb repressive complex 1 initiates and maintains tailless repression in Drosophila embryo.
    3. Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
      Title: Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
    4. Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
      Title: Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.
    5. The chromodomain is required for Pc-mediated Ci transcription.
      Title: Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila.
    6. Fsh physically interacts with Pc-Sce complex.Pc is required for Ci transcription.
      Title: Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).
    7. Pc of the PRC1 complex play a distinct role in modulating Life Span in flies. This protein influences on Life Span via pathways independent of its Polycomb Repressive Complex 1 functions, with distinct effects on response to Oxidative Stress.
      Title: Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster.
    8. Pc mediates Abd-B repression and this mechanism dependents on H3K27me3 in the Drosophila testis.
      Title: Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
    9. we demonstrate that the evolutionary conserved Lim3 core promoter provides basic Lim3 expression, whereas structural changes in the Lim3 PRE of distal promoter provide stage-, and tissue-specific Lim3 expression. Therefore, we hypothesize that PcG/TrxG proteins, which are directly involved in Lim3 transcription regulation, participate in lifespan control
      Title: Polycomb/Trithorax group-dependent regulation of the neuronal gene Lim3 involved in Drosophila lifespan control.
    10. Drosophila Mbf1 associates with E(z) mRNA and protects it from degradation by the exoribonuclease Pacman (Pcm), thereby ensuring Polycomb silencing.
      Title: Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, abdomen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycomb
    Names
    CG32443-PA
    Pc-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21306138..21318020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079475.3 → NP_524199.1  polycomb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26017, Q9VP49
      UniProtKB/TrEMBL
      Q541F9
      Related
      FBpp0078059
      Conserved Domains (1) summary
      smart00298
      Location:25 → 77
      CHROMO; Chromatin organization modifier domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26017.1 P26017
    Q541F9 Q541F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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