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    Mhc Myosin heavy chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35007, updated on 27-Mar-2024

    Summary

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    Official Symbol
    Mhcprovided by FlyBase
    Official Full Name
    Myosin heavy chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264695
    Locus tag
    Dmel_CG17927
    See related
    AllianceGenome:FB:FBgn0264695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bsh; CG17927; chr2L:16765388..16765564; chr2L:16781880..16782040; Dm II; Dmel\CG17927; DmMHC; DROMHC; DroMII; ifm(2)2; Ifm(2)2; ifm(2)RU1; Ifm(2)RU1; ifm(2)RU2; l(2)36Ae; l(2)k10423; l(2)M66; mhc; MHC; Mhc36B; mMHC; Mrp; MRP; MyHC; Myo; Myo6; Myosin; Nup; Sht; sMHC; Stp
    Summary
    Enables microfilament motor activity and protein homodimerization activity. A structural constituent of muscle. Involved in several processes, including adult somatic muscle development; epithelial cell migration; and myofibril assembly. Located in A band and polytene chromosome puff. Is expressed in several structures, including circulatory system; digestive system; extended germ band embryo; gonad; and muscle system. Used to study cardiomyopathy (multiple) and muscle tissue disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including arthrogryposis multiplex congenita; cardiomyopathy (multiple); congenital heart disease (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    36B1-36B1; 2-53 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16766566..16788766)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16766566..16788766)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Cytochrome b5-related Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insect Sf9 cells are suitable for functional expression of insect, but not vertebrate, striated muscle myosin. Liu C, et al. Biochem Biophys Res Commun, 2022 Dec 20. PMID 36308905
    2. Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure. Kronert WA, et al. Biology (Basel), 2022 Jul 29. PMID 36009764, Free PMC Article
    3. Prolonged myosin binding increases muscle stiffness in Drosophila models of Freeman-Sheldon syndrome. Bell KM, et al. Biophys J, 2021 Mar 2. PMID 33524372, Free PMC Article
    4. Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism. Guo Y, et al. Skelet Muscle, 2020 Aug 15. PMID 32799913, Free PMC Article
    5. 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway. Wang M, et al. Biochem Pharmacol, 2020 Oct. PMID 32653593

    See all (611) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
      Title: Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
    2. Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
      Title: Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
    3. Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain.
      Title: Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain.
    4. Atypical Myosin Tunes Dendrite Arbor Subdivision.
      Title: Atypical Myosin Tunes Dendrite Arbor Subdivision.
    5. Hypertrophic cardiomyopathy causative mutation R249Q alters flight muscle contractility and flight performance.
      Title: The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production.
    6. Here we report the first x-ray crystal structure of an insect myosin: the D melanogaster skeletal muscle myosin II embryonic isoform (EMB). Using our system for recombinant expression of myosin heavy chain (MHC) proteins in whole transgenic flies, we prepared and crystallized stable proteolytic S1-like fragments containing the entire EMB motor domain bound to an essential light chain
      Title: X-ray Crystallographic and Molecular Dynamic Analyses of Drosophila melanogaster Embryonic Muscle Myosin Define Domains Responsible for Isoform-Specific Properties.
    7. Findings indicate that the Freeman Sheldon Syndrome (FSS) contracture syndrome mutations lead to muscle structural defects and functional deficits in Drosophila, possibly mediated by the reduced ATPase activity of the mutant Myosin heavy chain (MHC) proteins.
      Title: Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.
    8. Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.
      Title: Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.
    9. We conclude that MHC isoforms can alter FSA and hence cyclical power generation but that isoforms can only endow a muscle type with moderate FSA Highly SA muscle types, such as IFM, likely use a different or additional mechanism.
      Title: The Drosophila indirect flight muscle myosin heavy chain isoform is insufficient to transform the jump muscle into a highly stretch-activated muscle type.
    10. Introduction of a mutation (R759E) in the converter domain inhibits the steady-state ATPase of myosin S1, whereas an additional mutation in the relay domain (N509K) is able to restore the ATPase.
      Title: The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myosin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myosin II filament assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle myosin thick filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle myosin thick filament HDA PubMed 

    General protein information

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    Preferred Names
    myosin heavy chain
    Names
    CG17927-PA
    CG17927-PB
    CG17927-PC
    CG17927-PD
    CG17927-PE
    CG17927-PF
    CG17927-PG
    CG17927-PH
    CG17927-PI
    CG17927-PK
    CG17927-PL
    CG17927-PM
    CG17927-PN
    CG17927-PO
    CG17927-PP
    CG17927-PQ
    CG17927-PR
    CG17927-PS
    CG17927-PT
    CG17927-PU
    CG17927-PV
    Mhc-PA
    Mhc-PB
    Mhc-PC
    Mhc-PD
    Mhc-PE
    Mhc-PF
    Mhc-PG
    Mhc-PH
    Mhc-PI
    Mhc-PK
    Mhc-PL
    Mhc-PM
    Mhc-PN
    Mhc-PO
    Mhc-PP
    Mhc-PQ
    Mhc-PR
    Mhc-PS
    Mhc-PT
    Mhc-PU
    Mhc-PV
    Not-upheld
    Shrunken-thorax
    beta-myosin heavy chain
    chain
    heavy chain
    indirect flight muscle (2) RU1
    indirect flight muscle (2) RU2
    muscle myosin
    muscle myosin II
    muscle myosin II heavy chain
    muscle myosin heavy chain
    muscle myosin-II
    muscle specific myosin II
    myosin
    myosin HC
    myosin II heavy chain
    myosin heavy
    myosin heavy Chain-PF
    myosin heavy-chain
    myosin heavy-chain protein
    myosin rod protein
    myosin-heavy chain
    samba
    sarcomeric myosin heavy-chain
    shrunken thorax
    stuckup
    NP_001162990.1
    NP_001162991.1
    NP_001162992.1
    NP_001246048.1
    NP_001246049.1
    NP_001246050.1
    NP_001246051.1
    NP_001303327.1
    NP_523587.4
    NP_723999.1
    NP_724000.1
    NP_724001.1
    NP_724002.2
    NP_724003.1
    NP_724004.1
    NP_724005.1
    NP_724006.1
    NP_724007.1
    NP_724008.1
    NP_724009.1
    NP_724010.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16766566..16788766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165190.4 → NP_724008.1  myosin heavy chain, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080463
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_165181.3 → NP_723999.1  myosin heavy chain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      Related
      FBpp0080455
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    3. NM_165182.3 → NP_724000.1  myosin heavy chain, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      UniProtKB/TrEMBL
      E1JHJ3
      Related
      FBpp0080452
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    4. NM_165183.3 → NP_724001.1  myosin heavy chain, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      Related
      FBpp0080456
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. NM_001259119.2 → NP_001246048.1  myosin heavy chain, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423, M9NF46
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    6. NM_165185.3 → NP_724003.1  myosin heavy chain, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      Related
      FBpp0080458
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    7. NM_165186.3 → NP_724004.1  myosin heavy chain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724004.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080457
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    8. NM_001169519.2 → NP_001162990.1  myosin heavy chain, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423, E1JHJ4
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    9. NM_165187.3 → NP_724005.1  myosin heavy chain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080453
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    10. NM_165188.3 → NP_724006.1  myosin heavy chain, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080460
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    11. NM_078863.6 → NP_523587.4  myosin heavy chain, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523587.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080459
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    12. NM_165191.3 → NP_724009.1  myosin heavy chain, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080462
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    13. NM_165192.4 → NP_724010.1  myosin heavy chain, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080464
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    14. NM_001169521.2 → NP_001162992.1  myosin heavy chain, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423, E1JHJ5
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    15. NM_165189.3 → NP_724007.1  myosin heavy chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423
      Related
      FBpp0080454
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    16. NM_001169520.3 → NP_001162991.1  myosin heavy chain, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      UniProtKB/TrEMBL
      E1JHJ3
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    17. NM_001259122.1 → NP_001246051.1  myosin heavy chain, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423, M9ND95
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    18. NM_001259120.1 → NP_001246049.1  myosin heavy chain, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      UniProtKB/TrEMBL
      M9NCU7
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    19. NM_001316398.1 → NP_001303327.1  myosin heavy chain, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      UniProtKB/TrEMBL
      A0A0S0WIH4
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    20. NM_165184.3 → NP_724002.2  myosin heavy chain, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724002.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18392, O18393, P05661, Q24412, Q7JN62, Q7JN63, Q7JQ08, Q7JQ09, Q7M4K4, Q8INZ9, Q8IP00, Q8IP01, Q8IP02, Q8IP03, Q8IP04, Q8IP05, Q8IP06, Q8IP07, Q8IP08, Q8IP09, Q8IP10, Q9TY21, Q9TY22, Q9TYD7, Q9VJI3
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)

    21. NM_001259121.2 → NP_001246050.1  myosin heavy chain, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A423, M9NEP1
      Conserved Domains (7) summary
      cl14654
      Location:1557 → 1877
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00242
      Location:81 → 777
      MYSc; Myosin. Large ATPases
      cd14909
      Location:100 → 765
      MYSc_Myh1_insects_crustaceans; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:842 → 1897
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1739 → 1825
      TMPIT; TMPIT-like protein
      cl21478
      Location:1671 → 1771
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WIH4 A0A0S0WIH4
    E1JHJ3 E1JHJ3
    E1JHJ4 E1JHJ4
    E1JHJ5 E1JHJ5
    M9NCU7 M9NCU7
    M9ND95 M9ND95
    M9NEP1 M9NEP1
    M9NF46 M9NF46
    P05661.4 P05661
    Q24410 Q24410
    Q24411 Q24411
    Q26433 Q26433

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