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    mei-W68 meiotic W68 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768853, updated on 29-Dec-2023

    Summary

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    Official Symbol
    mei-W68provided by FlyBase
    Official Full Name
    meiotic W68provided by FlyBase
    Primary source
    FLYBASE:FBgn0002716
    Locus tag
    Dmel_CG7753
    See related
    AllianceGenome:FB:FBgn0002716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30132; CG7753; Dmel\CG7753; l(2)k05603; mei; mei W-68; mei-w68; Mei-w68; Mei-W68; meiW68; MeiW68; Spo-11; spo11; Spo11; SPO11; W68
    Summary
    Predicted to enable DNA binding activity. Involved in meiosis I cell cycle process and meiotic DNA double-strand break processing. Predicted to be active in nuclear chromosome. Is expressed in several structures, including embryonic/larval anterior midgut; embryonic/larval central nervous system; embryonic/larval fat body; and gonad. Orthologous to human SPO11 (SPO11 initiator of meiotic double stranded breaks). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    56D9-56D9; 2-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19456170..19459523)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15343675..15347028)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 56D Neighboring gene uncharacterized protein Neighboring gene par-1 Neighboring gene Tubulin-binding cofactor B Neighboring gene Outer segment 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Normal synaptonemal complex and abnormal recombination nodules in two alleles of the Drosophila meiotic mutant mei-W68. Carpenter AT. Genetics, 2003 Apr. PMID 12702679, Free PMC Article
    2. Topoisomerase II is required for the proper separation of heterochromatic regions during Drosophila melanogaster female meiosis. Hughes SE, et al. PLoS Genet, 2014 Oct. PMID 25340780, Free PMC Article
    3. Meiosis. Searching for a partner. Haber JE. Science, 1998 Feb 6. PMID 9480551
    4. Models of germ cell development and their application for toxicity studies. Ferreira DW, et al. Environ Mol Mutagen, 2015 Oct. PMID 25821157, Free PMC Article
    5. The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γ-H2AV). Lake CM, et al. G3 (Bethesda), 2013 Sep 4. PMID 23833215, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that Drosophila mei-W68/SPO11 drives oncogenesis by causing DNA damage in a somatic tissue, hence providing the first instance in which a SPO11 orthologous is unequivocally shown to have an oncogenic role.
      Title: An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early meiotic recombination nodule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late meiotic recombination nodule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oocyte karyosome formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    meiotic W68
    Names
    CG7753-PA
    mei-W68-PA
    NP_995901.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19456170..19459523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206179.3 → NP_995901.1  meiotic W68 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KPA5
      UniProtKB/TrEMBL
      B6UX12
      Conserved Domains (3) summary
      cd00223
      Location:161 → 315
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      COG1697
      Location:3 → 327
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]
      pfam04406
      Location:50 → 113
      TP6A_N; Type IIB DNA topoisomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KPA5.1 Q7KPA5

    Gene LinkOut

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