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    ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6093, updated on 3-Dec-2017
    Official Symbol
    ROCK1provided by HGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:10251
    See related
    Ensembl:ENSG00000067900 MIM:601702; Vega:OTTHUMG00000131723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROCK-I; P160ROCK
    Summary
    This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.1), fat (RPKM 16.6) and 25 other tissues See more
    Orthologs
    Location:
    18q11.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (20949740..21111851, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (18529701..18691812, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 30B pseudogene Neighboring gene RNA, U6 small nuclear 721, pseudogene Neighboring gene vomeronasal 1 receptor 75 pseudogene Neighboring gene ribosomal protein L21 pseudogene 128 Neighboring gene RNA, U6 small nuclear 120, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ROCK1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
    Tat tat HIV-1 Tat downregulates OCLN (occludin) and LRP1 and upregulates AGER (RAGE), and in a RhoA/ROCK1 dependent manner as shown through hydroxyfasudil inhibition in hCMEC/D3 cells PubMed
    tat HIV-1 Tat-mediated downregulation of occludin expression requires activities of the RhoA and p160-Rho-associated coiled kinase (ROCK) proteins in primary human brain micro vascular endothelial cells PubMed
    matrix gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
    gag HIV-1 p17-mediated activation of the Rho/ROCK-signaling pathway is required for p17-mediated monocyte adhesion and migration PubMed
    gag HIV-1 p17-induced activation of PTEN is regulated by RhoA-associated kinase (ROCK) PubMed

    Go to the HIV-1, Human Interaction Database

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    • Axon guidance, conserved biosystem (from KEGG)
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    • Axon guidance, organism-specific biosystem (from REACTOME)
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    • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHA forward signaling, organism-specific biosystem
      EPHA forward signaling
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      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
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      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
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    • Focal adhesion, conserved biosystem (from KEGG)
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      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
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    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
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    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
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    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
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      Pathways in cancer, organism-specific biosystem
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      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
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    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
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    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
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      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
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      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
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    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
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    • Shigellosis, organism-specific biosystem (from KEGG)
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    • Signal Transduction, organism-specific biosystem (from REACTOME)
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      Signaling events mediated by PRL, organism-specific biosystem
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      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
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    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • PRO0435, MGC43611, MGC131603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP-Rho binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    apical constriction IEA
    Inferred from Electronic Annotation
    more info
     
    bleb assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cortical actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    execution phase of apoptosis TAS
    Traceable Author Statement
    more info
     
    leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte tethering or rolling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane to membrane docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myoblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of bicellular tight junction assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of myosin-light-chain-phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of myosin-light-chain-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of establishment of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of establishment of endothelial barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stress fiber assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    smooth muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    bleb IEA
    Inferred from Electronic Annotation
    more info
     
    centriole IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    rho-associated protein kinase 1
    Names
    p160 ROCK-1
    renal carcinoma antigen NY-REN-35
    NP_005397.1
    XP_011524439.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042178.2 RefSeqGene

      Range
      5001..167112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005406.2NP_005397.1  rho-associated protein kinase 1

      See identical proteins and their annotated locations for NP_005397.1

      Status: REVIEWED

      Source sequence(s)
      AC036178, AK057038, AU121527, U43195
      Consensus CDS
      CCDS11870.2
      UniProtKB/Swiss-Prot
      Q13464
      Related
      ENSP00000382697.1, OTTHUMP00000162514, ENST00000399799.2, OTTHUMT00000254641
      Conserved Domains (7) summary
      cd11639
      Location:489554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0419
      Location:4221027
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:12291275
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11191225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:9491014
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      20949740..21111851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526137.2XP_011524439.1  rho-associated protein kinase 1 isoform X1

      Conserved Domains (6) summary
      cd00029
      Location:766812
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:656762
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      TIGR02168
      Location:2634
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00169
      Location:658745
      PH; PH domain
      pfam08912
      Location:486551
      Rho_Binding; Rho Binding
      cl00087
      Location:2691
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      18456721..18618879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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