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    Eif4e2 eukaryotic translation initiation factor 4E member 2 [ Mus musculus (house mouse) ]

    Gene ID: 26987, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eif4e2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E member 2provided by MGI
    Primary source
    MGI:MGI:1914440
    See related
    Ensembl:ENSMUSG00000026254 AllianceGenome:MGI:1914440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4el3; D0H0S6743E; 2700069E09Rik
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. Is expressed in early conceptus; embryo; primary oocyte; and secondary oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C5; 1 44.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87141633..87168210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87213911..87240488)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene cholinergic receptor, nicotinic, gamma polypeptide Neighboring gene STARR-seq mESC enhancer starr_01608 Neighboring gene STARR-seq mESC enhancer starr_01609 Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187 Neighboring gene EF hand domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_01611 Neighboring gene predicted gene, 41911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Wiebe S, et al. Mol Brain, 2023 Jan 18. PMID 36650535, Free PMC Article
    2. The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Wiebe S, et al. Mol Autism, 2020 Nov 23. PMID 33225984, Free PMC Article
    3. Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28487484, Free PMC Article
    4. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. von Stechow L, et al. Mol Cell Biol, 2015 Apr. PMID 25624349, Free PMC Article
    5. Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation. Villaescusa JC, et al. PLoS One, 2009. PMID 19365557, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
      Title: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
    2. The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
      Title: The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
    3. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
      Title: microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
    4. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with Eif4e2. In turn, this causes Eif4e2 recruitment to the mRNA cap, where it is known to compete with eIF4E.
      Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
    5. Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation.[4EHP]
      Title: Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E type 2
    Names
    eIF-4E type 2
    eIF4E type 2
    eIF4E-2
    eIF4E-like protein 4E-LP
    eukaryotic translation initiation factor 4E like 3
    mRNA cap-binding protein type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039169.1 → NP_001034258.1  eukaryotic translation initiation factor 4E type 2 isoform 2

      See identical proteins and their annotated locations for NP_001034258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK017221
      Consensus CDS
      CCDS15131.1
      UniProtKB/TrEMBL
      D3Z730, Q0P688
      Related
      ENSMUSP00000108857.4, ENSMUST00000113231.4
      Conserved Domains (1) summary
      pfam01652
      Location:50 → 208
      IF4E; Eukaryotic initiation factor 4E

    2. NM_001039170.1 → NP_001034259.1  eukaryotic translation initiation factor 4E type 2 isoform 1

      See identical proteins and their annotated locations for NP_001034259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC102611, AK032965
      Consensus CDS
      CCDS35652.1
      UniProtKB/Swiss-Prot
      O88503, Q3UCK2, Q8BMB3
      UniProtKB/TrEMBL
      Q3UUT0
      Related
      ENSMUSP00000108859.2, ENSMUST00000113233.8
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 213
      IF4E; Eukaryotic initiation factor 4E

    3. NM_001347083.1 → NP_001334012.1  eukaryotic translation initiation factor 4E type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102611
      Consensus CDS
      CCDS83571.1
      UniProtKB/TrEMBL
      D3Z729, Q3UUT0
      Related
      ENSMUSP00000108861.2, ENSMUST00000113235.8
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 213
      IF4E; Eukaryotic initiation factor 4E

    4. NM_023314.3 → NP_075803.2  eukaryotic translation initiation factor 4E type 2 isoform 3

      See identical proteins and their annotated locations for NP_075803.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK032965, AK076067
      Consensus CDS
      CCDS15130.1
      UniProtKB/TrEMBL
      G3X9H1, Q9D334
      Related
      ENSMUSP00000075699.6, ENSMUST00000076362.12
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 213
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87141633..87168210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165581.1 → XP_036021474.1  eukaryotic translation initiation factor 4E type 2 isoform X1

      UniProtKB/TrEMBL
      Q9D334
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 214
      IF4E; Eukaryotic initiation factor 4E

    2. XM_036165586.1 → XP_036021479.1  eukaryotic translation initiation factor 4E type 2 isoform X3

      UniProtKB/TrEMBL
      Q9D334
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 214
      IF4E; Eukaryotic initiation factor 4E

    3. XM_006529674.4 → XP_006529737.1  eukaryotic translation initiation factor 4E type 2 isoform X7

      UniProtKB/TrEMBL
      D3YUV9, Q80ZJ3
      Related
      ENSMUSP00000053403.8, ENSMUST00000050876.14
      Conserved Domains (1) summary
      pfam01652
      Location:55 → 214
      IF4E; Eukaryotic initiation factor 4E

    4. XM_030254746.1 → XP_030110606.1  eukaryotic translation initiation factor 4E type 2 isoform X5

      UniProtKB/TrEMBL
      Q9D334
      Conserved Domains (1) summary
      pfam01652
      Location:50 → 209
      IF4E; Eukaryotic initiation factor 4E

    5. XM_030254745.1 → XP_030110605.1  eukaryotic translation initiation factor 4E type 2 isoform X4

      UniProtKB/TrEMBL
      D3Z730
      Conserved Domains (1) summary
      pfam01652
      Location:50 → 209
      IF4E; Eukaryotic initiation factor 4E

    6. XM_036165583.1 → XP_036021476.1  eukaryotic translation initiation factor 4E type 2 isoform X2

      UniProtKB/TrEMBL
      Q9D334
      Conserved Domains (1) summary
      pfam01652
      Location:50 → 209
      IF4E; Eukaryotic initiation factor 4E

    7. XM_036165589.1 → XP_036021482.1  eukaryotic translation initiation factor 4E type 2 isoform X6

      UniProtKB/TrEMBL
      D3Z730
      Conserved Domains (1) summary
      pfam01652
      Location:50 → 209
      IF4E; Eukaryotic initiation factor 4E

    RNA

    1. XR_004942584.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMB3.1 GenPept UniProtKB/Swiss-Prot:Q8BMB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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