Snmp1 Sensory neuron membrane protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Snmp1provided by FlyBase
Official Full Name: Sensory neuron membrane protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0260004
Locus tag: Dmel_CG7000
See related: AllianceGenome:FB:FBgn0260004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7000; Dmel\CG7000; snmp; Snmp; SNMP; snmp1; SNMP1
Summary: Predicted to enable scavenger receptor activity. Involved in several processes, including cellular response to pheromone; detection of chemical stimulus involved in sensory perception of smell; and pupariation. Located in cilium; dendrite; and neuronal cell body. Is expressed in several structures, including adult external head; embryonic/larval garland cell; gonad; ring gland; and sensory neurons. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 93C2-93C2; 3-71 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21165167..21168205, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16990889..16993927, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Snmp1 Microplitis mediator (Hymenoptera: Braconidae) orthologue (MmedSNMP1) was mainly expressed in sensilla placodea of antennae and possibly involved in perceiving plant volatiles and sex pheromones.
Title: Molecular characterization and expression of sensory neuron membrane proteins in the parasitoid Microplitis mediator (Hymenoptera: Braconidae).
SNMP1 funnels hydrophobic pheromones from the extracellular fluid to integral membrane receptors.
Title: A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism.
Our results thus clarify SNMP1 as an important player required for the rapid kinetics of the pheromone response in insects.
Title: Requirement for Drosophila SNMP1 for rapid activation and termination of pheromone-induced activity.
results show highly regulated expression patterns, with three genes crq, pes and Snmp being upregulated in steroidogenic tissues at the onset of pupariation when steroidogenesis is crucial
Title: Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster.
SNMP is a signaling component required for pheromone sensitivity in Drosophila.
Title: SNMP is a signaling component required for pheromone sensitivity in Drosophila.
a Drosophila melanogaster CD36 homologue, Sensory neuron membrane protein (SNMP), is expressed in a population of olfactory sensory neurons (OSNs) implicated in pheromone detection.
Title: An essential role for a CD36-related receptor in pheromone detection in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed