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    PLCD3 phospholipase C delta 3 [ Sus scrofa (pig) ]

    Gene ID: 100521111, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLCD3provided by VGNC
    Official Full Name
    phospholipase C delta 3provided by VGNC
    Primary source
    VGNC:VGNC:91518
    See related
    Ensembl:ENSSSCG00000017338
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in ovary (RPKM 20.9), subcutaneous adipose (RPKM 8.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See PLCD3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (18281507..18305516)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (18530472..18551197)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene N-myristoyltransferase 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene complement C1q like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      18281507..18305516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003131325.4 → XP_003131373.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

      UniProtKB/TrEMBL
      A0A4X1TDM6, A0A8D1D3A7, A0A8D1MVH7, A0A8D1WPZ9, F1RR07
      Related
      ENSSSCP00000018370.3, ENSSSCT00000018874.5
      Conserved Domains (7) summary
      cd00275
      Location:655 → 779
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08630
      Location:332 → 626
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:226 → 782
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:68 → 163
      PH; PH domain
      pfam09279
      Location:251 → 332
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand

    2. XM_021066845.1 → XP_020922504.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

      UniProtKB/TrEMBL
      A0A4X1TDM6, A0A8D1D3A7, A0A8D1MVH7
      Conserved Domains (4) summary
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand
      cl14615
      Location:332 → 625
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl27705
      Location:226 → 781
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

    3. XM_013980896.2 → XP_013836350.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TDM6, A0A8D1D3A7, A0A8D1MVH7
      Related
      ENSSSCP00000061487.2, ENSSSCT00000077866.2
      Conserved Domains (7) summary
      cd00275
      Location:623 → 747
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08630
      Location:300 → 594
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:194 → 750
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:29 → 145
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:36 → 131
      PH; PH domain
      pfam09279
      Location:219 → 300
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:165 → 214
      EF-hand_10; EF hand
    Nucleotide Protein
    Heading Accession and Version

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