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    FAM213B family with sequence similarity 213 member B [ Homo sapiens (human) ]

    Gene ID: 127281, updated on 20-Feb-2017
    Official Symbol
    FAM213Bprovided by HGNC
    Official Full Name
    family with sequence similarity 213 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:28390
    See related
    Ensembl:ENSG00000157870 Vega:OTTHUMG00000000847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf93
    Orthologs
    Location:
    1p36.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (2586460..2591469)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2517899..2522908)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115110 Neighboring gene uncharacterized LOC100996583 Neighboring gene TNF receptor superfamily member 14 Neighboring gene membrane metalloendopeptidase like 1 Neighboring gene uncharacterized LOC105378597 Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene uncharacterized LOC105378603 Neighboring gene uncharacterized LOC105378602

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC26818, DKFZp547M123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antioxidant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    prostaglandin-F synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    prostamide/prostaglandin F synthase
    Names
    prostamide/PG F synthase
    prostamide/PGF synthase
    thioredoxin-type PGF synthase
    NP_001182665.1
    NP_001182666.1
    NP_001182667.1
    NP_001182669.1
    NP_001182670.1
    NP_689584.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195736.1NP_001182665.1  prostamide/prostaglandin F synthase isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
      Source sequence(s)
      AK057027, AK075273, BM976058, DC351872, DC407959
      Consensus CDS
      CCDS72690.1
      UniProtKB/Swiss-Prot
      Q8TBF2
      UniProtKB/TrEMBL
      A0A0A0MT35
      Related
      ENSP00000413218, ENST00000444521
      Conserved Domains (1) summary
      cd02970
      Location:48215
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    2. NM_001195737.1NP_001182666.1  prostamide/prostaglandin F synthase isoform c

      See identical proteins and their annotated locations for NP_001182666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
      Source sequence(s)
      AK075273, AK303504, BM976058, DC351872, DC407959
      UniProtKB/Swiss-Prot
      Q8TBF2
      Conserved Domains (1) summary
      cd02970
      Location:48153
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    3. NM_001195738.1NP_001182667.1  prostamide/prostaglandin F synthase isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two different splice sites in the coding region which changes the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a.
      Source sequence(s)
      AK075273, AK291908, BM976058, DC351872, DC407959
      UniProtKB/Swiss-Prot
      Q8TBF2
      Related
      ENSP00000367684, OTTHUMP00000000970, ENST00000378427, OTTHUMT00000002403
      Conserved Domains (1) summary
      cd02970
      Location:48184
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    4. NM_001195740.1NP_001182669.1  prostamide/prostaglandin F synthase isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
      Source sequence(s)
      AK075273, AK316243, BM976058, DC351872, DC407959
      Consensus CDS
      CCDS72691.1
      UniProtKB/Swiss-Prot
      Q8TBF2
      UniProtKB/TrEMBL
      A0A0A0MRV4
      Related
      ENSP00000367682, ENST00000378425
      Conserved Domains (1) summary
      cd02970
      Location:48153
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    5. NM_001195741.1NP_001182670.1  prostamide/prostaglandin F synthase isoform f

      See identical proteins and their annotated locations for NP_001182670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
      Source sequence(s)
      AK075273, AK298926, BM976058, DC351872, DC407959
      Consensus CDS
      CCDS55564.1
      UniProtKB/Swiss-Prot
      Q8TBF2
      Related
      ENSP00000443605, OTTHUMP00000274612, ENST00000537325, OTTHUMT00000473549
      Conserved Domains (1) summary
      cd02970
      Location:48153
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    6. NM_152371.3NP_689584.2  prostamide/prostaglandin F synthase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in an internal coding region exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
      Source sequence(s)
      AK075273, BC022547, BM976058, DC351872, DC407959
      Consensus CDS
      CCDS44.2
      UniProtKB/Swiss-Prot
      Q8TBF2
      Related
      ENSP00000394405, OTTHUMP00000000968, ENST00000419916, OTTHUMT00000002401
      Conserved Domains (1) summary
      cd02970
      Location:48197
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RNA

    1. NR_036637.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate 5'-most exon and an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK075273, BM976058, BQ709693, DA495138
    2. NR_036638.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate 5'-most exon and two alternate internal splice sites, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK075273, BI908668, BM976058, DA292832, DA495138
      Related
      ENST00000484099

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      2586460..2591469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540664.1XP_011538966.1  prostamide/prostaglandin F synthase isoform X1

      See identical proteins and their annotated locations for XP_011538966.1

      Conserved Domains (1) summary
      cd02970
      Location:48140
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    2. XM_011540665.1XP_011538967.1  prostamide/prostaglandin F synthase isoform X3

      See identical proteins and their annotated locations for XP_011538967.1

      Conserved Domains (1) summary
      cd02970
      Location:48140
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    3. XM_011540666.1XP_011538968.1  prostamide/prostaglandin F synthase isoform X4

      See identical proteins and their annotated locations for XP_011538968.1

      UniProtKB/TrEMBL
      J3KPF5
      Related
      ENSP00000367681, OTTHUMP00000000969, ENST00000378424, OTTHUMT00000002402
      Conserved Domains (1) summary
      cd02970
      Location:48202
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    4. XM_006710354.3XP_006710417.1  prostamide/prostaglandin F synthase isoform X2

      See identical proteins and their annotated locations for XP_006710417.1

      Conserved Domains (1) summary
      cd02970
      Location:48153
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187515.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      137650..142659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      2504978..2509987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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