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    Casp6 caspase 6 [ Mus musculus (house mouse) ]

    Gene ID: 12368, updated on 7-May-2017
    Official Symbol
    Casp6provided by MGI
    Official Full Name
    caspase 6provided by MGI
    Primary source
    MGI:MGI:1312921
    See related
    Ensembl:ENSMUSG00000027997 Vega:OTTMUSG00000028845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mch2; CASP-6
    Summary
    This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    3; 3 G3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (129901415..129914112)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (129604343..129617020)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XIIA Neighboring gene predicted gene, 46825 Neighboring gene predicted gene, 40150 Neighboring gene mitochondrial calcium uniporter dominant negative beta subunit Neighboring gene predicted gene, 40151 Neighboring gene Sec24 related gene family, member B (S. cerevisiae)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acute inflammatory response to non-antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to staurosporine ISO
    Inferred from Sequence Orthology
    more info
     
    execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of retinal cell programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    caspase-6
    Names
    apoptotic protease Mch-2
    NP_033941.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009811.4NP_033941.3  caspase-6 precursor

      See identical proteins and their annotated locations for NP_033941.3

      Status: REVIEWED

      Source sequence(s)
      AC118620, AK168842, AV048874, BY265671
      Consensus CDS
      CCDS17838.1
      UniProtKB/Swiss-Prot
      O08738
      UniProtKB/TrEMBL
      Q3TPJ9
      Related
      ENSMUSP00000029626.8, OTTMUSP00000036607, ENSMUST00000029626.8, OTTMUST00000071443
      Conserved Domains (1) summary
      smart00115
      Location:20272
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      129901415..129914112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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