Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pink1 PTEN induced putative kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298575, updated on 8-Oct-2017
    Official Symbol
    Pink1provided by RGD
    Official Full Name
    PTEN induced putative kinase 1provided by RGD
    Primary source
    RGD:1305769
    See related
    Ensembl:ENSRNOG00000015385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156677146..156689258, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (160425715..160437827, complement)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene kinesin family member 17 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene cytidine deaminase Neighboring gene cytidine deaminase-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Mitophagy, organism-specific biosystem (from REACTOME)
      Mitophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
      Pink/Parkin Mediated Mitophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC189438

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    C3HC4-type RING finger domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    C3HC4-type RING finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to hydrogen sulfide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    establishment of protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    maintenance of protein location in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of protein location in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-serine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catecholamine secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cristae formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cristae formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitophagy in response to mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of hydrogen peroxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    astrocyte projection IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase PINK1, mitochondrial
    NP_001100164.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106694.1NP_001100164.1  serine/threonine-protein kinase PINK1, mitochondrial

      See identical proteins and their annotated locations for NP_001100164.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      D3Z9M9
      Related
      ENSRNOP00000058880.1, ENSRNOT00000065497.2
      Conserved Domains (1) summary
      cl21453
      Location:162240
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      156677146..156689258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      148924018..148936130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center