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    UHMK1 U2AF homology motif kinase 1 [ Homo sapiens (human) ]

    Gene ID: 127933, updated on 2-Oct-2018

    Summary

    Official Symbol
    UHMK1provided by HGNC
    Official Full Name
    U2AF homology motif kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:19683
    See related
    Ensembl:ENSG00000152332 MIM:608849; Vega:OTTHUMG00000031373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIS; KIST; P-CIP2
    Summary
    The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 18.6), lymph node (RPKM 18.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See UHMK1 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (162497174..162529629)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162466964..162499419)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 1B Neighboring gene uncharacterized LOC105373471 Neighboring gene SLAM family member 6 pseudogene 1 Neighboring gene uncharacterized LOC105371497 Neighboring gene uncharacterized LOC102724358 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 2 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23015, DKFZp434C1613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IC
    Inferred by Curator
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transferase activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Kist
    Names
    KIS protein kinase
    PAM COOH-terminal interactor protein 2
    U2AF homology motif (UHM) kinase 1
    kinase interacting with leukemia-associated gene (stathmin)
    NP_001171692.1
    NP_653225.2
    NP_787062.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050728.1 RefSeqGene

      Range
      5632..37456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184763.1NP_001171692.1  serine/threonine-protein kinase Kist isoform 2

      See identical proteins and their annotated locations for NP_001171692.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK058195, AL359699
      Consensus CDS
      CCDS53423.1
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000441226.1, ENST00000545294.5
      Conserved Domains (2) summary
      cd12465
      Location:244331
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      cl21453
      Location:16234
      PKc_like; Protein Kinases, catalytic domain
    2. NM_144624.2NP_653225.2  serine/threonine-protein kinase Kist isoform 3

      See identical proteins and their annotated locations for NP_653225.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL359699, BC026046
      Consensus CDS
      CCDS53424.1
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000446416.1, ENST00000538489.5
      Conserved Domains (2) summary
      cd14020
      Location:22308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
      cl17169
      Location:318341
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_175866.4NP_787062.1  serine/threonine-protein kinase Kist isoform 1

      See identical proteins and their annotated locations for NP_787062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ536197, AL359699
      Consensus CDS
      CCDS1239.1
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000420270.1, OTTHUMP00000029529, ENST00000489294.1, OTTHUMT00000076788
      Conserved Domains (2) summary
      cd12465
      Location:318405
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      cd14020
      Location:22308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      162497174..162529629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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