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    THRAP3 thyroid hormone receptor associated protein 3 [ Homo sapiens (human) ]

    Gene ID: 9967, updated on 19-Aug-2018

    Summary

    Official Symbol
    THRAP3provided by HGNC
    Official Full Name
    thyroid hormone receptor associated protein 3provided by HGNC
    Primary source
    HGNC:HGNC:22964
    See related
    Ensembl:ENSG00000054118 MIM:603809; Vega:OTTHUMG00000007866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCLAF2; TRAP150
    Expression
    Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See THRAP3 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (36224412..36305357)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36690017..36770958)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 3 Neighboring gene MAP7 domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 131, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 10257 and 14041 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 4 Neighboring gene SH3 domain containing 21 Neighboring gene eva-1 homolog B Neighboring gene serine/threonine kinase 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with thyroid hormone receptor associated protein 3 (THRAP3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human thyroid hormone receptor associated protein 3 (THRAP3) at amino acid residues 473-474 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22082, MGC133082, MGC133083

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear receptor transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin D receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with exon-exon junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thyroid hormone receptor-associated protein 3
    Names
    BCLAF1 and THRAP3 family member 2
    TR-associated protein, 150-kDa
    thyroid hormone receptor-associated protein complex 150 kDa component
    thyroid hormone receptor-associated protein, 150 kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321471.1NP_001308400.1  thyroid hormone receptor-associated protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114484, AI754117, AK025735, BC112350, HY001123
      Consensus CDS
      CCDS405.1
      UniProtKB/Swiss-Prot
      Q9Y2W1
      Related
      ENSP00000433825.1, OTTHUMP00000230679, ENST00000469141.6, OTTHUMT00000023220
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. NM_001321473.1NP_001308402.1  thyroid hormone receptor-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI754117, AK025735, BC112330, HY001123
      UniProtKB/Swiss-Prot
      Q9Y2W1
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. NM_005119.3NP_005110.2  thyroid hormone receptor-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_005110.2

      Status: VALIDATED

      Source sequence(s)
      AI754117, AK025735, BC112350, BG572651
      Consensus CDS
      CCDS405.1
      UniProtKB/Swiss-Prot
      Q9Y2W1
      Related
      ENSP00000346634.5, OTTHUMP00000009597, ENST00000354618.9, OTTHUMT00000021688
      Conserved Domains (1) summary
      pfam15440
      Location:191769
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      36224412..36305357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451302.1XP_024307070.1  thyroid hormone receptor-associated protein 3 isoform X1

      Conserved Domains (1) summary
      pfam15440
      Location:1382
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. XM_024451301.1XP_024307069.1  thyroid hormone receptor-associated protein 3 isoform X1

      Conserved Domains (1) summary
      pfam15440
      Location:1382
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RNA

    1. XR_002958230.1 RNA Sequence

    2. XR_002958231.1 RNA Sequence

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