cxcr4.L C-X-C motif chemokine receptor 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cxcr4.L
Official Full Name: C-X-C motif chemokine receptor 4 L homeolog
Primary source: Xenbase:XB-GENE-489921
Locus tag: XELAEV_18044533mg
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fb22; hm89; lap3; lcr1; npyr; cd184; cxcr4; lestr; npy3r; npyrl; hsy3rr; npyy3r; xCXCR4; cxcr4-a; cxcr4-b; CXC-R4-A; CXCR-4-A
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (63711637..63715059, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (53185755..53189231, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
Title: Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables C-C chemokine binding	IEA Inferred from Electronic Annotation more info
enables C-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables C-X-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within definitive hemopoiesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell migration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 4-A

Names: SDF-1 receptor-A; Stromal cell-derived factor 1 receptor-A; chemokine (C-X-C motif) receptor 4 L homeolog; chemokine receptor 4; stromal cell-derived factor 1 receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137581.1 → NP_001131053.1 C-X-C chemokine receptor type 4-A

See identical proteins and their annotated locations for NP_001131053.1

Status: PROVISIONAL

Source sequence(s)

BC073603

UniProtKB/Swiss-Prot

Q9YGC3

Conserved Domains (2) summary

pfam00001
Location:59 → 309

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12109
Location:10 → 42

CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

63711637..63715059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)