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    Me1 malic enzyme 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24552, updated on 4-Feb-2018
    Official Symbol
    Me1provided by RGD
    Official Full Name
    malic enzyme 1provided by RGD
    Primary source
    RGD:3074
    See related
    Ensembl:ENSRNOG00000009715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MOD1
    Summary
    catalyzes the NADP+ dependent conversion of S-malate to pyruvate [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 685.9), Muscle (RPKM 322.4) and 7 other tissues See more
    Orthologs
    Location:
    8q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94256830..94368834, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (93769078..93863611, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene protease, serine, 35 Neighboring gene synaptosome associated protein 91

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    malic enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    malic enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    malic enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    malate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of NADP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    NADP-dependent malic enzyme
    Names
    NADP-ME
    cytosolic malic enzyme 1
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
    malic enzyme 1, NADP(+)-dependent, cytosolic
    malic enzyme 1, soluble
    NP_036732.2
    XP_008764661.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012600.2NP_036732.2  NADP-dependent malic enzyme

      Status: VALIDATED

      Source sequence(s)
      AABR03062333, AABR03064582, AABR03064643, CB613492, CB810743, CO395247, CO560778, H34871
      Related
      ENSRNOP00000013244.6, ENSRNOT00000013244.6
      Conserved Domains (3) summary
      cd05312
      Location:270547
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:3551
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:79260
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      94256830..94368834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766439.2XP_008764661.1  NADP-dependent malic enzyme isoform X1

      Conserved Domains (3) summary
      cd05312
      Location:245522
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:2526
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:54235
      malic; Malic enzyme, N-terminal domain

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      87151761..87246579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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