GPX1 glutathione peroxidase GPX1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GPX1
Gene description: glutathione peroxidase GPX1
Primary source: SGD:S000001509
Locus tag: YKL026C
See related: AllianceGenome:SGD:S000001509
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to oxidative stress and peroxisome organization. Located in peroxisomal matrix. Is extrinsic component of mitochondrial outer membrane. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Sedaghatian type and type 2 diabetes mellitus. Orthologous to several human genes including GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (389380..389883, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

redox regulation of Gpx1 seems to be involved in the mechanism of peroxisome formation.
Title: Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium.
The expression of GPX1 is induced by glucose starvation and treatment with calcium chloride involving the Ras/cAMP pathway and Snf1.
Title: Regulatory mechanism for expression of GPX1 in response to glucose starvation and Ca in Saccharomyces cerevisiae: involvement of Snf1 and Ras/cAMP pathway in Ca signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid-hydroperoxide glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione peroxidase GPX1

NP_012899.3

EC 1.11.1.24

EC 1.11.1.9

Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; GPX1 has a paralog, HYR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

389380..389883 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179592.3 → NP_012899.3 TPA: glutathione peroxidase GPX1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012899.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXQ8, P36014

UniProtKB/TrEMBL

A0A6A5PS17, A6ZZT7, B3LR57, C7GRI6, C8ZCE1, G2WI03, N1P0C0

Conserved Domains (1) summary

COG0386
Location:1 → 161

BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]